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Human immunodeficiency virus infection in gynaecologyby: H. Sebitloane
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Notes for this articleAfrican women have a lower immune status in their uterine tracts? If they have a higher estrogen, this might make sense because estrogen supression reduces the antigen presenting quality of cells in the vagina as well as the uterus. And thus a higher estrogen would mean poorer immune status in the reproductive tract and more chances of HIV infection.
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AbstractBy the end of 2002, an estimated 40 million people were infected with the human immunodeficiency virus worldwide, the greater proportion of these infections occur in sub-Saharan Africa, where the prevalence is substantially high amongst young women. Females are said to be particularly more susceptible to HIV infection, and it is reported that HIV transmission from men to women is more efficient than from women to men. The presence of a sexually transmitted infection (STI) is known to increase the risk of both acquiring and transmitting the HI virus, whilst the presence of HIV infection, especially advanced disease, may alter the clinical presentation, course and response to conservative treatment for most STIs, as well as pelvic inflammatory disease. Though there are theoretical concerns regarding some methods of fertility control and the risk of HIV acquisition, most contraceptive methods can be used by infected women under close medical surveillance. HIV infection has been associated with an increased prevalence or a more aggressive behavior of certain gynaecological neoplasms. This probably occurs as a result of alterations in the immune response in the lower genital tract to HIV.
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