@article{citeulike:3662896, abstract = {The present study aimed to determine adrenopause or reduction of serum adrenal androgens with age at high altitude and at sea level. It was a cross-sectional study performed in 210 women resident at high altitude (4340 m) and 123 women living in Lima (150 m), aged 20-70 years. Fasting early morning blood samples were obtained. Serum dehydroepiandrosterone (DHEA), DHEA sulphate (DHEAS), androstenedione, testosterone and estradiol were measured by radioimmunoassay. Serum testosterone concentrations were greater in women living at high altitude than in those resident at sea level. Serum concentrations of DHEA, DHEAS and androstenedione were lower in women living at high altitude than in those living at sea level. The DHEAS/DHEA ratio was significantly greater, and the androstenedione/testosterone ratio was lower in samples from women living at high altitude. Among women older than 50 years of age, a greater decline in serum concentrations of DHEA was observed in those living at high altitude than in those living at sea level. Among women 60-70 years of age, serum concentrations of DHEA at high altitude were 46.9\% of those in women of the same age living at sea level. Decay of DHEAS at sea level and at high altitude occurred from the age of 40 years. The decline was faster at high altitude than at sea level, and in women aged 60-70 years serum values of DHEAS at high altitude were 56\% of those at sea level. In the same age group, serum concentrations of androstenedione among those native to high altitudes were 27.34\% of the value at sea level. At sea level, serum testosterone concentrations did not change with age from 20 to 70 years. In women aged 20-39 years and 50-59 years, serum testosterone concentrations were greater at high altitude than at sea level (P 10.1677/joe.0.1730095}, author = {Gonzales, G. F. and Gonez, C. and Villena, A.}, citeulike-article-id = {3662896}, citeulike-linkout-0 = {http://dx.doi.org/10.1677/joe.0.1730095}, citeulike-linkout-1 = {http://joe.endocrinology-journals.org/cgi/content/abstract/173/1/95}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11927388}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11927388}, comment = {An interesting study looking at endocrine hormone levels by altitude and age (Climate) --> Are these levels consistent -> determined by naturally selected genes? --> Would these differences persist if the population moved elsewhere? --> What evolutionary advantages do these populations have - in having this type of distribution of adrenal hormones? == BY ALTITUDE == * Serum testosterone greater at high altitude. * Serum DHEA, DHEAS and androstenedione lower at high altitude. * DHEAS/DHEA ratio significantly greater at high altitude. * Androstenedione/testosterone ratio lower at high altitude. (Testosterone higher in high altitude -> Need for more manual labour and haemoglobin oxygen binding?) '''What is the role/interaction between DHEA and Testosterone?''' == BY AGE == * > 50 Years + High Altitude: Greater decline in serum DHEA. * 60 - 70 years + High Altitude: Serum DHEA LOWER (46.9\%) than at sea level == Comparisons and Conclusions == * Decay of DHEAS: >40 years. * Decline faster at high altitude. * 60-70 years: DHEAS at high altitude were 56\% LOWER of those at sea level. * 60-70 years: Androstenedione at high altitudes were 27.34\% LOWER of the value at sea level. * At Sea Level: Testosterone did not change with age from 20 to 70 years. * 20-39 years and 50-59 years: Testosterone higher at high altitude than at sea level (P<0.05). * 60-70 years, the concentrations were similar in those living at sea level and at high altitude. * Serum testosterone/estradiol ratio increased with age (P<0.0034 and P<0.0001 respectively). Testosterone more/Estrogen Less * Ratio increased at an earlier age among those living at high altitude (40-49 years) than among those living at sea level (50-59 years). * Altitude (P<0.0001) and greater chronological age (P<0.001) were associated with lower serum DHEAS concentrations. * DHEAS was related to chronological age (P<0.0001). * Low serum androstenedione concentrations were related to living at high altitude at birth and greater chronological age (P<0.0001). In conclusion, adrenopause is attained earlier and is of greater magnitude at high altitude than at sea level. (Do women at higher altitude have earlier menopause? Greater menopause symptoms? More aggressive breast cancers? Does climate play a role in natural selection of immune/hormone traits in these women?}, day = {1}, doi = {10.1677/joe.0.1730095}, journal = {J Endocrinol}, keywords = {adrenal, adrenopause, africa, altitude, hormone, population, read, reference, steroid}, month = {April}, number = {1}, pages = {95--101}, posted-at = {2008-11-23 02:37:48}, priority = {2}, title = {Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude}, url = {http://dx.doi.org/10.1677/joe.0.1730095}, volume = {173}, year = {2002} }

TY - JOUR ID - citeulike:3662896 L3 - citeulike-article-id:3662896 N2 - The present study aimed to determine adrenopause or reduction of serum adrenal androgens with age at high altitude and at sea level. It was a cross-sectional study performed in 210 women resident at high altitude (4340 m) and 123 women living in Lima (150 m), aged 20-70 years. Fasting early morning blood samples were obtained. Serum dehydroepiandrosterone (DHEA), DHEA sulphate (DHEAS), androstenedione, testosterone and estradiol were measured by radioimmunoassay. Serum testosterone concentrations were greater in women living at high altitude than in those resident at sea level. Serum concentrations of DHEA, DHEAS and androstenedione were lower in women living at high altitude than in those living at sea level. The DHEAS/DHEA ratio was significantly greater, and the androstenedione/testosterone ratio was lower in samples from women living at high altitude. Among women older than 50 years of age, a greater decline in serum concentrations of DHEA was observed in those living at high altitude than in those living at sea level. Among women 60-70 years of age, serum concentrations of DHEA at high altitude were 46.9% of those in women of the same age living at sea level. Decay of DHEAS at sea level and at high altitude occurred from the age of 40 years. The decline was faster at high altitude than at sea level, and in women aged 60-70 years serum values of DHEAS at high altitude were 56% of those at sea level. In the same age group, serum concentrations of androstenedione among those native to high altitudes were 27.34% of the value at sea level. At sea level, serum testosterone concentrations did not change with age from 20 to 70 years. In women aged 20-39 years and 50-59 years, serum testosterone concentrations were greater at high altitude than at sea level (P 10.1677/joe.0.1730095 IS - 1 JF - J Endocrinol EP - 101 TI - Adrenopause or decline of serum adrenal androgens with age in women living at sea level or at high altitude VL - 173 SP - 95 KW - adrenal KW - adrenopause KW - africa KW - altitude KW - hormone KW - population KW - read KW - reference KW - steroid N1 - An interesting study looking at endocrine hormone levels by altitude and age (Climate) --> Are these levels consistent -> determined by naturally selected genes? --> Would these differences persist if the population moved elsewhere? --> What evolutionary advantages do these populations have - in having this type of distribution of adrenal hormones? == BY ALTITUDE == * Serum testosterone greater at high altitude. * Serum DHEA, DHEAS and androstenedione lower at high altitude. * DHEAS/DHEA ratio significantly greater at high altitude. * Androstenedione/testosterone ratio lower at high altitude. (Testosterone higher in high altitude -> Need for more manual labour and haemoglobin oxygen binding?) '''What is the role/interaction between DHEA and Testosterone?''' == BY AGE == * > 50 Years + High Altitude: Greater decline in serum DHEA. * 60 - 70 years + High Altitude: Serum DHEA LOWER (46.9%) than at sea level == Comparisons and Conclusions == * Decay of DHEAS: >40 years. * Decline faster at high altitude. * 60-70 years: DHEAS at high altitude were 56% LOWER of those at sea level. * 60-70 years: Androstenedione at high altitudes were 27.34% LOWER of the value at sea level. * At Sea Level: Testosterone did not change with age from 20 to 70 years. * 20-39 years and 50-59 years: Testosterone higher at high altitude than at sea level (P<0.05). * 60-70 years, the concentrations were similar in those living at sea level and at high altitude. * Serum testosterone/estradiol ratio increased with age (P<0.0034 and P<0.0001 respectively). Testosterone more/Estrogen Less * Ratio increased at an earlier age among those living at high altitude (40-49 years) than among those living at sea level (50-59 years). * Altitude (P<0.0001) and greater chronological age (P<0.001) were associated with lower serum DHEAS concentrations. * DHEAS was related to chronological age (P<0.0001). * Low serum androstenedione concentrations were related to living at high altitude at birth and greater chronological age (P<0.0001). In conclusion, adrenopause is attained earlier and is of greater magnitude at high altitude than at sea level. (Do women at higher altitude have earlier menopause? Greater menopause symptoms? More aggressive breast cancers? Does climate play a role in natural selection of immune/hormone traits in these women? AU - Gonzales, GF AU - Gonez, C AU - Villena, A PY - 2002/04/01/ UR - http://dx.doi.org/10.1677/joe.0.1730095 ER -