Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes. Export

@article{citeulike:3680144, abstract = {This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity.}, author = {Moinfar, F.}, citeulike-article-id = {3680144}, citeulike-linkout-0 = {http://dx.doi.org/10.1159/000123850}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18544967}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18544967}, comment = {Even more histopathological/immunological hetergeneity in basal breast cancer (than previously suspected) exists. Are we going to find out that basal breast cancer is made up of a handful of other forms of breast cancer??!}, doi = {10.1159/000123850}, issn = {1423-0291}, journal = {Pathobiology : journal of immunopathology, molecular and cellular biology}, keywords = {basal, breast, cancer, heterogeneity, histopath, review, subtypes, thelist}, number = {2}, pages = {119--131}, posted-at = {2008-11-24 02:15:53}, priority = {2}, title = {Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes.}, url = {http://dx.doi.org/10.1159/000123850}, volume = {75}, year = {2008} }

TY - JOUR ID - citeulike:3680144 L3 - citeulike-article-id:3680144 N2 - This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity. IS - 2 JF - Pathobiology : journal of immunopathology, molecular and cellular biology SN - 1423-0291 EP - 131 TI - Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes. VL - 75 SP - 119 KW - basal KW - breast KW - cancer KW - heterogeneity KW - histopath KW - review KW - subtypes KW - thelist N1 - Even more histopathological/immunological hetergeneity in basal breast cancer (than previously suspected) exists. Are we going to find out that basal breast cancer is made up of a handful of other forms of breast cancer??! AU - Moinfar, F PY - 2008/// UR - http://dx.doi.org/10.1159/000123850 ER -