![]() |
CiteULike | ![]() |
Zephyrus's CiteULike | ![]() |
![]() |
|
![]() |
Register | ![]() |
Log in | ![]() |
Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes.by: F. Moinfar
Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 75, No. 2. (2008), pp. 119-131.
|
Reviews
[Write a review of this article]
Notes for this articleEven more histopathological/immunological hetergeneity in basal breast cancer (than previously suspected) exists. Are we going to find out that basal breast cancer is made up of a handful of other forms of breast cancer??!
Find related articles from these CiteULike users
Find related articles with these CiteULike tags
Posting History
AbstractThis review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity.
BibTeX record
RIS record