[Hormonal status and overexpression of HER2 in breast cancer, Cancerology department of Treichville UHC. Preliminary results] Export

@article{citeulike:3680160, abstract = {AIMS: Main objective: determine the profile of the hormonal receptors and HER2 in order to optimize the patient's treatment by hormonotherapy and to propose targeted therapeutic to the few patients can procure themselves, when the indication is put. Secondary objectives: show the feasibility of these exams in sub-Saharan Africa and also the necessity to improve the technical tray permitting to do these exams in routine thus. PATIENTS AND METHODS: Preliminary results of a prospective, descriptive study, on 10 months, achieved to the Cancerology service of Treichville CHU in Abidjan (Ivory Coast). Our results were about 22 patients. RESULTS: The middle age of our patients was of 42.7 years. The stages to the diagnosis were advanced (86\%) with nodes metastasis (77\%), 8 patients out of 20 were RH+ of which only one postmenopausal patient, 8 patients out of 20 were HER2+ of which 2 to 2++ and 6 to 3+++. The FISH test has been achieved for the 2 positive patients to 2 ++ by IHC and came back positive. One of patients HER2+ could have adjuvant Herceptin. CONCLUSION: Breast cancer is bad prognosis affection in our developing countries because of the patient's young age, of the advanced stages to the diagnosis. The knowledge of the status of the hormonal receptors and the HER2 over expression is necessary, as well the importance to pursue this survey and to set up an immunohistochemy unit in Ivory Coast. It will permit the realization in routine of these exams and, then, the improvement of the breast cancer patient's treatment.}, author = {Coulibaly, J. D. and Effi, A. B. and Horo, G. A. and Diabate, A. and Mbra, K. and Adoubi, I. and Toure, M. and Osseni, A. and Echimane, K. A.}, citeulike-article-id = {3680160}, citeulike-linkout-0 = {http://dx.doi.org/10.1684/bdc.2008.0701}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18829411}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18829411}, comment = {The abstract indicates that breast cancer is probably an aggressive disease in the sub-sahara. Therapeutic options are complicated and limited by the fact that hormone receptor profiles (via immunohistochemistry) are not available. {Article in in French. :(}}, day = {1}, doi = {10.1684/bdc.2008.0701}, issn = {1769-6917}, journal = {Bulletin du cancer}, keywords = {africa, estrogen, her2, hormone, ivory-coast, receptor, status, sub-sahara, therapy}, month = {October}, number = {9}, pages = {799--803}, posted-at = {2008-11-24 02:51:24}, priority = {2}, title = {[Hormonal status and overexpression of HER2 in breast cancer, Cancerology department of Treichville UHC. Preliminary results]}, url = {http://dx.doi.org/10.1684/bdc.2008.0701}, volume = {95}, year = {2008} }

TY - JOUR ID - citeulike:3680160 L3 - citeulike-article-id:3680160 N2 - AIMS: Main objective: determine the profile of the hormonal receptors and HER2 in order to optimize the patient's treatment by hormonotherapy and to propose targeted therapeutic to the few patients can procure themselves, when the indication is put. Secondary objectives: show the feasibility of these exams in sub-Saharan Africa and also the necessity to improve the technical tray permitting to do these exams in routine thus. PATIENTS AND METHODS: Preliminary results of a prospective, descriptive study, on 10 months, achieved to the Cancerology service of Treichville CHU in Abidjan (Ivory Coast). Our results were about 22 patients. RESULTS: The middle age of our patients was of 42.7 years. The stages to the diagnosis were advanced (86%) with nodes metastasis (77%), 8 patients out of 20 were RH+ of which only one postmenopausal patient, 8 patients out of 20 were HER2+ of which 2 to 2++ and 6 to 3+++. The FISH test has been achieved for the 2 positive patients to 2 ++ by IHC and came back positive. One of patients HER2+ could have adjuvant Herceptin. CONCLUSION: Breast cancer is bad prognosis affection in our developing countries because of the patient's young age, of the advanced stages to the diagnosis. The knowledge of the status of the hormonal receptors and the HER2 over expression is necessary, as well the importance to pursue this survey and to set up an immunohistochemy unit in Ivory Coast. It will permit the realization in routine of these exams and, then, the improvement of the breast cancer patient's treatment. IS - 9 JF - Bulletin du cancer SN - 1769-6917 EP - 803 TI - [Hormonal status and overexpression of HER2 in breast cancer, Cancerology department of Treichville UHC. Preliminary results] VL - 95 SP - 799 KW - africa KW - estrogen KW - her2 KW - hormone KW - ivory-coast KW - receptor KW - status KW - sub-sahara KW - therapy N1 - The abstract indicates that breast cancer is probably an aggressive disease in the sub-sahara. Therapeutic options are complicated and limited by the fact that hormone receptor profiles (via immunohistochemistry) are not available. {Article in in French. :(} AU - Coulibaly, JD AU - Effi, AB AU - Horo, GA AU - Diabate, A AU - Mbra, K AU - Adoubi, I AU - Toure, M AU - Osseni, A AU - Echimane, KA PY - 2008/10/01/ UR - http://dx.doi.org/10.1684/bdc.2008.0701 ER -