In Vivo Induction of Immune Responses to Pathogens by Conventional Dendritic Cells Export

@article{citeulike:3709715, abstract = {Specific defense mechanisms against pathogens are fulfilled by different subsets of nonmucosal conventional dendritic cells (DCs), including migratory Langerhans cells (LCs), dermal DCs, and resident CD8+ and CD8− DCs found in lymphoid organs. Dermal DCs capture antigens in the skin and migrate to lymph nodes, where they can transfer the antigens to CD8+ DCs and activate CD4+ T cells. Differential antigen-processing machinery grants CD8+ DCs a high efficiency in activating CD8+ T cells through crosspresentation, whereas CD8− DCs preferentially trigger CD4+ T cell responses. Recent findings have revealed the important role played by monocyte-derived DCs (mo-DCs), newly formed during infection, in activating CD4+ and CD8+ T cells, regulating immunoglobulin production, and killing pathogens. However, a number of controversial issues regarding the function of different DC subsets during viral, bacterial, and parasitic infections remain to be resolved.}, author = {Lopezbravo, M. and Ardavin, C.}, citeulike-article-id = {3709715}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2008.08.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1074761308003798}, day = {19}, doi = {10.1016/j.immuni.2008.08.008}, issn = {10747613}, journal = {Immunity}, keywords = {cell, dendritic, new-direction, urgent, vaccine}, month = {September}, number = {3}, pages = {343--351}, posted-at = {2008-11-26 23:30:27}, priority = {2}, title = {In Vivo Induction of Immune Responses to Pathogens by Conventional Dendritic Cells}, url = {http://dx.doi.org/10.1016/j.immuni.2008.08.008}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:3709715 L3 - citeulike-article-id:3709715 N2 - Specific defense mechanisms against pathogens are fulfilled by different subsets of nonmucosal conventional dendritic cells (DCs), including migratory Langerhans cells (LCs), dermal DCs, and resident CD8+ and CD8− DCs found in lymphoid organs. Dermal DCs capture antigens in the skin and migrate to lymph nodes, where they can transfer the antigens to CD8+ DCs and activate CD4+ T cells. Differential antigen-processing machinery grants CD8+ DCs a high efficiency in activating CD8+ T cells through crosspresentation, whereas CD8− DCs preferentially trigger CD4+ T cell responses. Recent findings have revealed the important role played by monocyte-derived DCs (mo-DCs), newly formed during infection, in activating CD4+ and CD8+ T cells, regulating immunoglobulin production, and killing pathogens. However, a number of controversial issues regarding the function of different DC subsets during viral, bacterial, and parasitic infections remain to be resolved. IS - 3 JF - Immunity SN - 10747613 EP - 351 TI - In Vivo Induction of Immune Responses to Pathogens by Conventional Dendritic Cells VL - 29 SP - 343 KW - cell KW - dendritic KW - new-direction KW - urgent KW - vaccine AU - Lopezbravo, M AU - Ardavin, C PY - 2008/09/19/ UR - http://dx.doi.org/10.1016/j.immuni.2008.08.008 ER -