Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. Export

@article{citeulike:3733846, abstract = {BACKGROUND: Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations. METHODS: We analyzed individual data from eight prospective studies of postmenopausal women. Data on BMI and prediagnostic estradiol levels were available for 624 case subjects and 1669 control subjects; data on the other sex hormones were available for fewer subjects. The relative risks (RRs) with 95\% confidence intervals (CIs) of breast cancer associated with increasing BMI were estimated by conditional logistic regression on case-control sets, matched within each study for age and recruitment date, and adjusted for parity. All statistical tests were two-sided. RESULTS: Breast cancer risk increased with increasing BMI (P(trend) =.002), and this increase in RR was substantially reduced by adjustment for serum estrogen concentrations. Adjusting for free estradiol reduced the RR for breast cancer associated with a 5 kg/m2 increase in BMI from 1.19 (95\% CI = 1.05 to 1.34) to 1.02 (95\% CI = 0.89 to 1.17). The increased risk was also substantially reduced after adjusting for other estrogens (total estradiol, non-sex hormone-binding globulin-bound estradiol, estrone, and estrone sulfate), and moderately reduced after adjusting for sex hormone-binding globulin, whereas adjustment for the androgens (androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and testosterone) had little effect on the excess risk. CONCLUSION: The results are compatible with the hypothesis that the increase in breast cancer risk with increasing BMI among postmenopausal women is largely the result of the associated increase in estrogens, particularly bioavailable estradiol.}, author = {Key, T. J. and Appleby, P. N. and Reeves, G. K. and Roddam, A. and Dorgan, J. F. and Longcope, C. and Stanczyk, F. Z. and Stephenson, H. E. and Falk, R. T. and Miller, R. and Schatzkin, A. and Allen, D. S. and Fentiman, I. S. and Key, T. J. and Wang, D. Y. and Dowsett, M. and Thomas, H. V. and Hankinson, S. E. and Toniolo, P. and Akhmedkhanov, A. and Koenig, K. and Shore, R. E. and Zeleniuch-Jacquotte, A. and Berrino, F. and Muti, P. and Micheli, A. and Krogh, V. and Sieri, S. and Pala, V. and Venturelli, E. and Secreto, G. and Barrett-Connor, E. and Laughlin, G. A. and Kabuto, M. and Akiba, S. and Stevens, R. G. and Neriishi, K. and Land, C. E. and Cauley, J. A. and Kuller, L. H. and Cummings, S. R. and Helzlsouer, K. J. and Alberg, A. J. and Bush, T. L. and Comstock, G. W. and Gordon, G. B. and Miller, S. R. and Longcope, C. and {}}, citeulike-article-id = {3733846}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12928347}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12928347}, issn = {1460-2105}, journal = {Journal of the National Cancer Institute}, keywords = {bmi, breast, cancer, estrogen, hormone, postmenopausal, superlist, thelist}, month = {August}, number = {16}, pages = {1218--1226}, posted-at = {2008-12-02 01:51:04}, priority = {2}, title = {Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12928347}, volume = {95}, year = {2003} }

TY - JOUR ID - citeulike:3733846 L3 - citeulike-article-id:3733846 N2 - BACKGROUND: Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations. METHODS: We analyzed individual data from eight prospective studies of postmenopausal women. Data on BMI and prediagnostic estradiol levels were available for 624 case subjects and 1669 control subjects; data on the other sex hormones were available for fewer subjects. The relative risks (RRs) with 95% confidence intervals (CIs) of breast cancer associated with increasing BMI were estimated by conditional logistic regression on case-control sets, matched within each study for age and recruitment date, and adjusted for parity. All statistical tests were two-sided. RESULTS: Breast cancer risk increased with increasing BMI (P(trend) =.002), and this increase in RR was substantially reduced by adjustment for serum estrogen concentrations. Adjusting for free estradiol reduced the RR for breast cancer associated with a 5 kg/m2 increase in BMI from 1.19 (95% CI = 1.05 to 1.34) to 1.02 (95% CI = 0.89 to 1.17). The increased risk was also substantially reduced after adjusting for other estrogens (total estradiol, non-sex hormone-binding globulin-bound estradiol, estrone, and estrone sulfate), and moderately reduced after adjusting for sex hormone-binding globulin, whereas adjustment for the androgens (androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and testosterone) had little effect on the excess risk. CONCLUSION: The results are compatible with the hypothesis that the increase in breast cancer risk with increasing BMI among postmenopausal women is largely the result of the associated increase in estrogens, particularly bioavailable estradiol. IS - 16 JF - Journal of the National Cancer Institute SN - 1460-2105 EP - 1226 TI - Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. VL - 95 SP - 1218 KW - bmi KW - breast KW - cancer KW - estrogen KW - hormone KW - postmenopausal KW - superlist KW - thelist AU - Key, TJ AU - Appleby, PN AU - Reeves, GK AU - Roddam, A AU - Dorgan, JF AU - Longcope, C AU - Stanczyk, FZ AU - Stephenson, HE AU - Falk, RT AU - Miller, R AU - Schatzkin, A AU - Allen, DS AU - Fentiman, IS AU - Key, TJ AU - Wang, DY AU - Dowsett, M AU - Thomas, HV AU - Hankinson, SE AU - Toniolo, P AU - Akhmedkhanov, A AU - Koenig, K AU - Shore, RE AU - Zeleniuch-Jacquotte, A AU - Berrino, F AU - Muti, P AU - Micheli, A AU - Krogh, V AU - Sieri, S AU - Pala, V AU - Venturelli, E AU - Secreto, G AU - Barrett-Connor, E AU - Laughlin, GA AU - Kabuto, M AU - Akiba, S AU - Stevens, RG AU - Neriishi, K AU - Land, CE AU - Cauley, JA AU - Kuller, LH AU - Cummings, SR AU - Helzlsouer, KJ AU - Alberg, AJ AU - Bush, TL AU - Comstock, GW AU - Gordon, GB AU - Miller, SR AU - Longcope, C PY - 2003/08/20/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12928347 ER -