Genetic Ancestry and Risk of Breast Cancer among U.S. Latinas Export

@article{citeulike:3753634, abstract = {U.S. Latinas have a lower incidence of breast cancer compared with non-Latina White women. This difference is partially explained by differences in the prevalence of known risk factors. Genetic factors may also contribute to this difference in incidence. Latinas are an admixed population with most of their genetic ancestry from Europeans and Indigenous Americans. We used genetic markers to estimate the ancestry of Latina breast cancer cases and controls and assessed the association with genetic ancestry, adjusting for reproductive and other risk factors. We typed a set of 106 ancestry informative markers in 440 Latina women with breast cancer and 597 Latina controls from the San Francisco Bay area and estimated genetic ancestry using a maximum likelihood method. Odds ratios (OR) and 95\% confidence intervals (95\% CI) for ancestry modeled as a continuous variable were estimated using logistic regression with known risk factors included as covariates. Higher European ancestry was associated with increased breast cancer risk. The OR for a 25\% increase in European ancestry was 1.79 (95\% CI, 1.28-2.79; P < 0.001). When known risk factors and place of birth were adjusted for, the association with European ancestry was attenuated but remained statistically significant (OR, 1.39; 95\% CI, 1.06-2.11; P = 0.013). Further work is needed to determine if the association is due to genetic differences between populations or possibly due to environmental factors not measured. [Cancer Res 2008;68(23):9723-8] 10.1158/0008-5472.CAN-08-2039}, author = {Fejerman, Laura and John, Esther M. and Huntsman, Scott and Beckman, Kenny and Choudhry, Shweta and Perez-Stable, Eliseo and Burchard, Esteban G. and Ziv, Elad}, citeulike-article-id = {3753634}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-08-2039}, citeulike-linkout-1 = {http://cancerres.aacrjournals.org/cgi/content/abstract/68/23/9723}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19047150}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19047150}, day = {1}, doi = {10.1158/0008-5472.CAN-08-2039}, journal = {Cancer Res}, keywords = {ancestry, breast, cancer, european, hispanic, risk, susceptibility, thelist}, month = {December}, number = {23}, pages = {9723--9728}, posted-at = {2008-12-07 18:57:24}, priority = {2}, title = {Genetic Ancestry and Risk of Breast Cancer among U.S. Latinas}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-08-2039}, volume = {68}, year = {2008} }

TY - JOUR ID - citeulike:3753634 L3 - citeulike-article-id:3753634 N2 - U.S. Latinas have a lower incidence of breast cancer compared with non-Latina White women. This difference is partially explained by differences in the prevalence of known risk factors. Genetic factors may also contribute to this difference in incidence. Latinas are an admixed population with most of their genetic ancestry from Europeans and Indigenous Americans. We used genetic markers to estimate the ancestry of Latina breast cancer cases and controls and assessed the association with genetic ancestry, adjusting for reproductive and other risk factors. We typed a set of 106 ancestry informative markers in 440 Latina women with breast cancer and 597 Latina controls from the San Francisco Bay area and estimated genetic ancestry using a maximum likelihood method. Odds ratios (OR) and 95% confidence intervals (95% CI) for ancestry modeled as a continuous variable were estimated using logistic regression with known risk factors included as covariates. Higher European ancestry was associated with increased breast cancer risk. The OR for a 25% increase in European ancestry was 1.79 (95% CI, 1.28-2.79; P < 0.001). When known risk factors and place of birth were adjusted for, the association with European ancestry was attenuated but remained statistically significant (OR, 1.39; 95% CI, 1.06-2.11; P = 0.013). Further work is needed to determine if the association is due to genetic differences between populations or possibly due to environmental factors not measured. [Cancer Res 2008;68(23):9723-8] 10.1158/0008-5472.CAN-08-2039 IS - 23 JF - Cancer Res EP - 9728 TI - Genetic Ancestry and Risk of Breast Cancer among U.S. Latinas VL - 68 SP - 9723 KW - ancestry KW - breast KW - cancer KW - european KW - hispanic KW - risk KW - susceptibility KW - thelist AU - Fejerman, Laura AU - John, Esther AU - Huntsman, Scott AU - Beckman, Kenny AU - Choudhry, Shweta AU - Perez-Stable, Eliseo AU - Burchard, Esteban AU - Ziv, Elad PY - 2008/12/01/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-08-2039 ER -