Effect of Dietary Intake of Phytoestrogens on Estrogen Receptor Status in Premenopausal Women With Breast Cancer Export

@article{citeulike:3993226, abstract = {Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR = 3.50; 95\% confidence interval, CI = 1.43–8.58) and daidzein (OR = 3.10; 95\% CI = 1.31–7.30). Low intake of the flavonoid kaempferol (OR = 0.36; 95\% CI = 0.16–0.83), the trace element boron (OR = 0.33; 95\% CI = 0.13–0.83), and the phytosterol \&b.beta;-sitosterol (OR = 0.42; 95\% CI = 0.18–0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment.}, author = {Touillaud, Marina S. and Pillow, Patricia C. and Jakovljevic, Jelena and Bondy, Melissa L. and Singletary, Eva S. and Li, Donghui and Chang, Shine}, citeulike-article-id = {3993226}, citeulike-linkout-0 = {http://dx.doi.org/10.1207/s15327914nc5102_6}, comment = {Did this relationship hold with adjustment for race? African-Americans don't really eat a lot of soy-rich food. Is cultural and dietary preferences masquerading as a biological factor in the determination of aggressive estrogen-receptor negative breast cancers?}, doi = {10.1207/s15327914nc5102_6}, journal = {Nutrition and Cancer}, keywords = {aggressiveness, breast, cancer, confounding-example, estrogen-receptor, phytoestrogen, race, thelist}, number = {2}, pages = {162--169}, posted-at = {2009-02-02 06:31:55}, priority = {2}, publisher = {Routledge}, title = {Effect of Dietary Intake of Phytoestrogens on Estrogen Receptor Status in Premenopausal Women With Breast Cancer}, url = {http://dx.doi.org/10.1207/s15327914nc5102_6}, volume = {51}, year = {2005} }

TY - JOUR ID - citeulike:3993226 L3 - citeulike-article-id:3993226 N2 - Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR = 3.50; 95% confidence interval, CI = 1.43–8.58) and daidzein (OR = 3.10; 95% CI = 1.31–7.30). Low intake of the flavonoid kaempferol (OR = 0.36; 95% CI = 0.16–0.83), the trace element boron (OR = 0.33; 95% CI = 0.13–0.83), and the phytosterol &b.beta;-sitosterol (OR = 0.42; 95% CI = 0.18–0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment. IS - 2 JF - Nutrition and Cancer EP - 169 TI - Effect of Dietary Intake of Phytoestrogens on Estrogen Receptor Status in Premenopausal Women With Breast Cancer PB - Routledge VL - 51 SP - 162 KW - aggressiveness KW - breast KW - cancer KW - confounding-example KW - estrogen-receptor KW - phytoestrogen KW - race KW - thelist N1 - Did this relationship hold with adjustment for race? African-Americans don't really eat a lot of soy-rich food. Is cultural and dietary preferences masquerading as a biological factor in the determination of aggressive estrogen-receptor negative breast cancers? AU - Touillaud, Marina AU - Pillow, Patricia AU - Jakovljevic, Jelena AU - Bondy, Melissa AU - Singletary, Eva AU - Li, Donghui AU - Chang, Shine PY - 2005/// UR - http://dx.doi.org/10.1207/s15327914nc5102_6 ER -