The Role of Stress Factors during Aging of the Immune System Export

@article{citeulike:4034441, abstract = {This manuscript reviews current evidence suggesting that aging of the immune system (immunosenescence) may be closely related to chronic stress and stress factors. Healthy aging has been associated with emotional distress in parallel to increased cortisol to dehydroepiandrosterone (DHEA) ratio. The impaired DHEA secretion together with the increase of cortisol results in an enhanced exposure of lymphoid cells to deleterious glucocorticoid actions. The lack of appropriated growth hormone signaling during immunosenescence is also discussed. It follows that altered neuroendocrine functions could be underlying several immunosenescence features. Indeed, changes in both innate and adaptive immune responses during aging are also similarly reported during chronic glucocorticoid exposure. In addition, chronically stressed elderly subjects may be particularly at risk of stress-related pathology because of further alterations in both neuroendocrine and immune systems. The accelerated senescent features induced by chronic stress include higher oxidative stress, reduced telomere length, chronic glucocorticoid exposure, thymic involution, changes in cellular trafficking, reduced cell-mediated immunity, steroid resistance, and chronic low-grade inflammation. These senescent features are related to increased morbidity and mortality among chronically stressed elderly people. Overall, these data suggest that chronic stress leads to premature aging of key allostatic systems involved in the adaptation of the organisms to environmental changes. Stress management and psychosocial support may thus promote a better quality of life for elderly people and at the same time reduce hospitalization costs.}, address = {Faculdade de Biocincias and Instituto de Pesquisas Biomdicas; Faculdade de Farmcia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, Brazil; LabVitrus, Porto Alegre, Brazil}, author = {Bauer, Mois\'{e}s E. and Moriguchi Jeckel, Cristina M. and Luz, Clarice}, citeulike-article-id = {4034441}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1749-6632.2008.03966.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19236337}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19236337}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122189835/ABSTRACT}, doi = {10.1111/j.1749-6632.2008.03966.x}, issn = {1749-6632}, journal = {Annals of the New York Academy of Sciences}, keywords = {ageing, immune, immunosenescence, senescence, stress, system}, number = {Neuroimmunomodulation: From Fundamental Biology to Therapy}, pages = {139--152}, posted-at = {2009-02-11 10:56:39}, priority = {2}, title = {The Role of Stress Factors during Aging of the Immune System}, url = {http://dx.doi.org/10.1111/j.1749-6632.2008.03966.x}, volume = {1153}, year = {2009} }

TY - JOUR ID - citeulike:4034441 L3 - citeulike-article-id:4034441 N2 - This manuscript reviews current evidence suggesting that aging of the immune system (immunosenescence) may be closely related to chronic stress and stress factors. Healthy aging has been associated with emotional distress in parallel to increased cortisol to dehydroepiandrosterone (DHEA) ratio. The impaired DHEA secretion together with the increase of cortisol results in an enhanced exposure of lymphoid cells to deleterious glucocorticoid actions. The lack of appropriated growth hormone signaling during immunosenescence is also discussed. It follows that altered neuroendocrine functions could be underlying several immunosenescence features. Indeed, changes in both innate and adaptive immune responses during aging are also similarly reported during chronic glucocorticoid exposure. In addition, chronically stressed elderly subjects may be particularly at risk of stress-related pathology because of further alterations in both neuroendocrine and immune systems. The accelerated senescent features induced by chronic stress include higher oxidative stress, reduced telomere length, chronic glucocorticoid exposure, thymic involution, changes in cellular trafficking, reduced cell-mediated immunity, steroid resistance, and chronic low-grade inflammation. These senescent features are related to increased morbidity and mortality among chronically stressed elderly people. Overall, these data suggest that chronic stress leads to premature aging of key allostatic systems involved in the adaptation of the organisms to environmental changes. Stress management and psychosocial support may thus promote a better quality of life for elderly people and at the same time reduce hospitalization costs. IS - Neuroimmunomodulation: From Fundamental Biology to Therapy JF - Annals of the New York Academy of Sciences SN - 1749-6632 AD - Faculdade de Biocincias and Instituto de Pesquisas Biomdicas; Faculdade de Farmcia, Pontifcia Universidade Catlica do Rio Grande do Sul, Porto Alegre, Brazil; LabVitrus, Porto Alegre, Brazil EP - 152 TI - The Role of Stress Factors during Aging of the Immune System VL - 1153 SP - 139 KW - ageing KW - immune KW - immunosenescence KW - senescence KW - stress KW - system AU - Bauer, Moisés AU - Moriguchi Jeckel, Cristina AU - Luz, Clarice PY - 2009/// UR - http://dx.doi.org/10.1111/j.1749-6632.2008.03966.x ER -