Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 Export

@article{citeulike:4252095, abstract = {Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95\% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95\% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.}, author = {Ahmed, Shahana and Thomas, Gilles and Ghoussaini, Maya and Healey, Catherine S. and Humphreys, Manjeet K. and Platte, Radka and Morrison, Jonathan and Maranian, Melanie and Pooley, Karen A. and Luben, Robert and Eccles, Diana and Evans, D. Gareth and Fletcher, Olivia and Johnson, Nichola and Dos Santos Silva, Isabel and Peto, Julian and Stratton, Michael R. and Rahman, Nazneen and Jacobs, Kevin and Prentice, Ross and Anderson, Garnet L. and Rajkovic, Aleksandar and Curb, J. David and Ziegler, Regina G. and Berg, Christine D. and Buys, Saundra S. and Mccarty, Catherine A. and Feigelson, Heather S. and Calle, Eugenia E. and Thun, Michael J. and Diver, W. Ryan and Bojesen, Stig and Nordestgaard, Borge G. and Flyger, Henrik and Dork, Thilo and Schurmann, Peter and Hillemanns, Peter and Karstens, Johann H. and Bogdanova, Natalia V. and Antonenkova, Natalia N. and Zalutsky, Iosif V. and Bermisheva, Marina and Fedorova, Sardana and Khusnutdinova, Elza and Kang, Daehee and Yoo, Keun-Young and Noh, Dong Y. and Ahn, Sei-Hyun and Devilee, Peter and van Asperen, Christi J. and Tollenaar, R. A. E. M. and Seynaeve, Caroline and Garcia-Closas, Montserrat and Lissowska, Jolanta and Brinton, Louise and Peplonska, Beata and Nevanlinna, Heli and Heikkinen, Tuomas and Aittomaki, Kristiina and Blomqvist, Carl and Hopper, John L. and Southey, Melissa C. and Smith, Letitia and Spurdle, Amanda B. and Schmidt, Marjanka K. and Broeks, Annegien and van Hien, Richard R. and Cornelissen, Sten and Milne, Roger L. and Ribas, Gloria and Gonzalez-Neira, Anna and Benitez, Javier and Schmutzler, Rita K. and Burwinkel, Barbara and Bartram, Claus R. and Meindl, Alfons and Brauch, Hiltrud and Justenhoven, Christina and Hamann, Ute and Chang-Claude, Jenny and Hein, Rebecca and Wang-Gohrke, Shan and Lindblom, Annika and Margolin, Sara and Mannermaa, Arto and Kosma, Veli-Matti and Kataja, Vesa and Olson, Janet E. and Wang, Xianshu and Fredericksen, Zachary and Giles, Graham G. and Severi, Gianluca and Baglietto, Laura and English, Dallas R. and Hankinson, Susan E. and Cox, David G. and Kraft, Peter and Vatten, Lars J. and Hveem, Kristian and Kumle, Merethe and Sigurdson, Alice and Doody, Michele and Bhatti, Parveen and Alexander, Bruce H. and Hooning, Maartje J. and van den Ouweland, Ans M. W. and Oldenburg, Rogier A. and Schutte, Mieke and Hall, Per and Czene, Kamila and Liu, Jianjun and Li, Yuqing and Cox, Angela and Elliott, Graeme and Brock, Ian and Reed, Malcolm W. R. and Shen, Chen-Yang and Yu, Jyh-Cherng and Hsu, Giu-Cheng and Chen, Shou-Tung and Anton-Culver, Hoda and Ziogas, Argyrios and Andrulis, Irene L. and Knight, Julia A. and Beesley, Jonathan and Goode, Ellen L. and Couch, Fergus and Chenevix-Trench, Georgia and Hoover, Robert N. and Ponder, Bruce A. J. and Hunter, David J. and Pharoah, Paul D. P. and Dunning, Alison M. and Chanock, Stephen J. and Easton, Douglas F.}, citeulike-article-id = {4252095}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.354}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.354}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19330027}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19330027}, day = {29}, doi = {10.1038/ng.354}, issn = {1546-1718}, journal = {Nat Genet}, keywords = {breast, cancer, genes, susceptibility, thelist}, month = {May}, number = {5}, pages = {585--590}, posted-at = {2009-04-08 20:22:18}, priority = {2}, publisher = {Nature Publishing Group}, title = {Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2}, url = {http://dx.doi.org/10.1038/ng.354}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:4252095 L3 - citeulike-article-id:4252095 N2 - Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q. IS - 5 JF - Nat Genet SN - 1546-1718 EP - 590 TI - Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 PB - Nature Publishing Group VL - 41 SP - 585 KW - breast KW - cancer KW - genes KW - susceptibility KW - thelist AU - Ahmed, Shahana AU - Thomas, Gilles AU - Ghoussaini, Maya AU - Healey, Catherine AU - Humphreys, Manjeet AU - Platte, Radka AU - Morrison, Jonathan AU - Maranian, Melanie AU - Pooley, Karen AU - Luben, Robert AU - Eccles, Diana AU - Evans, Gareth AU - Fletcher, Olivia AU - Johnson, Nichola AU - Dos Santos Silva, Isabel AU - Peto, Julian AU - Stratton, Michael AU - Rahman, Nazneen AU - Jacobs, Kevin AU - Prentice, Ross AU - Anderson, Garnet AU - Rajkovic, Aleksandar AU - Curb, David AU - Ziegler, Regina AU - Berg, Christine AU - Buys, Saundra AU - Mccarty, Catherine AU - Feigelson, Heather AU - Calle, Eugenia AU - Thun, Michael AU - Diver, Ryan AU - Bojesen, Stig AU - Nordestgaard, Borge AU - Flyger, Henrik AU - Dork, Thilo AU - Schurmann, Peter AU - Hillemanns, Peter AU - Karstens, Johann AU - Bogdanova, Natalia AU - Antonenkova, Natalia AU - Zalutsky, Iosif AU - Bermisheva, Marina AU - Fedorova, Sardana AU - Khusnutdinova, Elza AU - Kang, Daehee AU - Yoo, Keun-Young AU - Noh, Dong AU - Ahn, Sei-Hyun AU - Devilee, Peter AU - van Asperen, Christi AU - Tollenaar, RAEM AU - Seynaeve, Caroline AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Brinton, Louise AU - Peplonska, Beata AU - Nevanlinna, Heli AU - Heikkinen, Tuomas AU - Aittomaki, Kristiina AU - Blomqvist, Carl AU - Hopper, John AU - Southey, Melissa AU - Smith, Letitia AU - Spurdle, Amanda AU - Schmidt, Marjanka AU - Broeks, Annegien AU - van Hien, Richard AU - Cornelissen, Sten AU - Milne, Roger AU - Ribas, Gloria AU - Gonzalez-Neira, Anna AU - Benitez, Javier AU - Schmutzler, Rita AU - Burwinkel, Barbara AU - Bartram, Claus AU - Meindl, Alfons AU - Brauch, Hiltrud AU - Justenhoven, Christina AU - Hamann, Ute AU - Chang-Claude, Jenny AU - Hein, Rebecca AU - Wang-Gohrke, Shan AU - Lindblom, Annika AU - Margolin, Sara AU - Mannermaa, Arto AU - Kosma, Veli-Matti AU - Kataja, Vesa AU - Olson, Janet AU - Wang, Xianshu AU - Fredericksen, Zachary AU - Giles, Graham AU - Severi, Gianluca AU - Baglietto, Laura AU - English, Dallas AU - Hankinson, Susan AU - Cox, David AU - Kraft, Peter AU - Vatten, Lars AU - Hveem, Kristian AU - Kumle, Merethe AU - Sigurdson, Alice AU - Doody, Michele AU - Bhatti, Parveen AU - Alexander, Bruce AU - Hooning, Maartje AU - van den Ouweland, Ans AU - Oldenburg, Rogier AU - Schutte, Mieke AU - Hall, Per AU - Czene, Kamila AU - Liu, Jianjun AU - Li, Yuqing AU - Cox, Angela AU - Elliott, Graeme AU - Brock, Ian AU - Reed, Malcolm AU - Shen, Chen-Yang AU - Yu, Jyh-Cherng AU - Hsu, Giu-Cheng AU - Chen, Shou-Tung AU - Anton-Culver, Hoda AU - Ziogas, Argyrios AU - Andrulis, Irene AU - Knight, Julia AU - Beesley, Jonathan AU - Goode, Ellen AU - Couch, Fergus AU - Chenevix-Trench, Georgia AU - Hoover, Robert AU - Ponder, Bruce AU - Hunter, David AU - Pharoah, Paul AU - Dunning, Alison AU - Chanock, Stephen AU - Easton, Douglas PY - 2009/05/29/ UR - http://dx.doi.org/10.1038/ng.354 ER -