Treatment Quality and Outcomes of African American Versus White Breast Cancer Patients: Retrospective Analysis of Southwest Oncology Studies S8814/S8897 Export

@article{citeulike:4279625, abstract = {PurposeWomen of African ancestry (AA) have lower WBC counts and are more likely to have treatment delays and discontinue adjuvant breast cancer therapy early compared with white women. We assessed the association between race and treatment discontinuation/delay, WBC counts, and survival in women enrolled onto breast cancer clinical trials. Patients and MethodsAA and white women from Southwest Oncology Group adjuvant breast cancer trials (S8814/S8897) were matched by age and protocol. Only the treatment arms in which patients were scheduled to receive six cycles of chemotherapy were analyzed. ResultsA total of 317 pairs of patients (n = 634) were analyzed. At baseline, AA women had higher body-surface area (P < .0001) and lower WBC (P = .0009). AA women were more likely to have tumors that were [\&ge;] 2 cm (P = .01) and hormone receptor negative (P < .0001). AA women, versus white women, were marginally more likely to discontinue treatment early (11\% v 7\%, respectively; P = .07) or have one or more treatment delays (85\% v 79\%, respectively; P = .07) and were significantly more likely to experience the combined end point (discontinuation/delay; 87\% v 81\%, respectively; P = .04). The mean relative dose-intensity (RDI) was similar for both groups (87\% in AA women v 86\% in white women); however, overall, 43\% had an RDI of less than 85\%. After adjusting for baseline WBC and prognostic factors in a multivariate model, AA women had worse disease-free survival (hazard ratio [HR] = 1.56; 95\% CI, 1.15 to 2.11; P = .005) and overall survival (HR = 1.95; 95\% CI, 1.36 to 2.78; P = .0002). The inclusion of RDI and treatment delivery/quality in the regression had little impact on the results. ConclusionOn cooperative group breast cancer trials, AA and white women had similar RDIs, but AA women were more likely to experience early discontinuation or treatment delay. Despite correcting for these factors and known predictors of outcome, AA women still had worse survival. 10.1200/JCO.2008.19.1163}, author = {Hershman, Dawn L. and Unger, Joseph M. and Barlow, William E. and Hutchins, Laura F. and Martino, Silvana and Osborne, C. Kent and Livingston, Robert B. and Albain, Kathy S.}, citeulike-article-id = {4279625}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2008.19.1163}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/27/13/2157.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/27/13/2157.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19307504}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19307504}, day = {1}, doi = {10.1200/JCO.2008.19.1163}, journal = {J Clin Oncol}, keywords = {african-american, outcomes, survival}, month = {May}, number = {13}, pages = {2157--2162}, posted-at = {2009-10-26 14:55:41}, priority = {2}, title = {Treatment Quality and Outcomes of African American Versus White Breast Cancer Patients: Retrospective Analysis of Southwest Oncology Studies S8814/S8897}, url = {http://dx.doi.org/10.1200/JCO.2008.19.1163}, volume = {27}, year = {2009} }

TY - JOUR ID - citeulike:4279625 L3 - citeulike-article-id:4279625 N2 - PurposeWomen of African ancestry (AA) have lower WBC counts and are more likely to have treatment delays and discontinue adjuvant breast cancer therapy early compared with white women. We assessed the association between race and treatment discontinuation/delay, WBC counts, and survival in women enrolled onto breast cancer clinical trials. Patients and MethodsAA and white women from Southwest Oncology Group adjuvant breast cancer trials (S8814/S8897) were matched by age and protocol. Only the treatment arms in which patients were scheduled to receive six cycles of chemotherapy were analyzed. ResultsA total of 317 pairs of patients (n = 634) were analyzed. At baseline, AA women had higher body-surface area (P < .0001) and lower WBC (P = .0009). AA women were more likely to have tumors that were [&ge;] 2 cm (P = .01) and hormone receptor negative (P < .0001). AA women, versus white women, were marginally more likely to discontinue treatment early (11% v 7%, respectively; P = .07) or have one or more treatment delays (85% v 79%, respectively; P = .07) and were significantly more likely to experience the combined end point (discontinuation/delay; 87% v 81%, respectively; P = .04). The mean relative dose-intensity (RDI) was similar for both groups (87% in AA women v 86% in white women); however, overall, 43% had an RDI of less than 85%. After adjusting for baseline WBC and prognostic factors in a multivariate model, AA women had worse disease-free survival (hazard ratio [HR] = 1.56; 95% CI, 1.15 to 2.11; P = .005) and overall survival (HR = 1.95; 95% CI, 1.36 to 2.78; P = .0002). The inclusion of RDI and treatment delivery/quality in the regression had little impact on the results. ConclusionOn cooperative group breast cancer trials, AA and white women had similar RDIs, but AA women were more likely to experience early discontinuation or treatment delay. Despite correcting for these factors and known predictors of outcome, AA women still had worse survival. 10.1200/JCO.2008.19.1163 IS - 13 JF - J Clin Oncol EP - 2162 TI - Treatment Quality and Outcomes of African American Versus White Breast Cancer Patients: Retrospective Analysis of Southwest Oncology Studies S8814/S8897 VL - 27 SP - 2157 KW - african-american KW - outcomes KW - survival AU - Hershman, Dawn AU - Unger, Joseph AU - Barlow, William AU - Hutchins, Laura AU - Martino, Silvana AU - Osborne, Kent AU - Livingston, Robert AU - Albain, Kathy PY - 2009/05/01/ UR - http://dx.doi.org/10.1200/JCO.2008.19.1163 ER -