Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours Export

@article{citeulike:4363639, abstract = {Clonal populations of mammalian cells are inherently heterogeneous. They contain cells that display non-genetic variability resulting from gene expression noise and the fact that gene networks have multiple stable states. These stable, heritable variants within one cell type can exhibit different levels of responsiveness to environmental conditions. Hence, they could in principle serve as a temporary substrate for natural selection in the absence of mutations. We suggest that such ubiquitous but non-genetic variability can contribute to the somatic evolution of cancer cells, hence accelerating tumour progression independently of genetic mutations.}, author = {Brock, Amy and Chang, Hannah and Huang, Sui}, citeulike-article-id = {4363639}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2556}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2556}, doi = {10.1038/nrg2556}, issn = {1471-0064}, journal = {Nature Reviews Genetics}, keywords = {cancer, evolution, heterogeneity, tumor}, month = {May}, number = {5}, pages = {336--342}, posted-at = {2009-06-13 03:05:18}, priority = {2}, publisher = {Nature Publishing Group}, title = {Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours}, url = {http://dx.doi.org/10.1038/nrg2556}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:4363639 L3 - citeulike-article-id:4363639 N2 - Clonal populations of mammalian cells are inherently heterogeneous. They contain cells that display non-genetic variability resulting from gene expression noise and the fact that gene networks have multiple stable states. These stable, heritable variants within one cell type can exhibit different levels of responsiveness to environmental conditions. Hence, they could in principle serve as a temporary substrate for natural selection in the absence of mutations. We suggest that such ubiquitous but non-genetic variability can contribute to the somatic evolution of cancer cells, hence accelerating tumour progression independently of genetic mutations. IS - 5 JF - Nature Reviews Genetics SN - 1471-0064 EP - 342 TI - Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours PB - Nature Publishing Group VL - 10 SP - 336 KW - cancer KW - evolution KW - heterogeneity KW - tumor AU - Brock, Amy AU - Chang, Hannah AU - Huang, Sui PY - 2009/05// UR - http://dx.doi.org/10.1038/nrg2556 ER -