Identification of downstream targets of estrogen and c-myc in breast cancer cells. Export

@article{citeulike:4488966, abstract = {Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are regulated by E and its downstream target c-myc, we compared transcript profiles of antiestrogens-arrested cells stimulated to reinitiate cell cycle progression by E treatment or c-myc induction. Approximately 2/3 of the probe sets significantly regulated by E (adjusted p < 0.01) increased in expression. Half of the E-regulated probe sets were also regulated by c-myc. Genes involved in cell growth, cell proliferation, and cell survival were over-represented in the E-regulated geneset. Analysis of selected candidates has identified a nucleolar protein whose expression is correlated with c-myc expression in BC cell lines. These data indicate that a significant component of E-induced mitogenesis is mediated by c-myc and that selected c-myc target genes may be surrogate markers of c-myc expression in BC.}, author = {Musgrove, E. A. and Sergio, C. M. and Anderson, L. R. and Inman, C. K. and McNeil, C. M. and Alles, M. C. and Gardiner-Garden, M. and Ormandy, C. J. and Butt, A. J. and Sutherland, R. L.}, citeulike-article-id = {4488966}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18497068}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18497068}, issn = {0065-2598}, journal = {Advances in experimental medicine and biology}, keywords = {breast, cancer, downstream, estrogen, target, thelist}, pages = {445--451}, posted-at = {2009-05-07 22:18:52}, priority = {2}, title = {Identification of downstream targets of estrogen and c-myc in breast cancer cells.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18497068}, volume = {617}, year = {2008} }

TY - JOUR ID - citeulike:4488966 L3 - citeulike-article-id:4488966 N2 - Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are regulated by E and its downstream target c-myc, we compared transcript profiles of antiestrogens-arrested cells stimulated to reinitiate cell cycle progression by E treatment or c-myc induction. Approximately 2/3 of the probe sets significantly regulated by E (adjusted p < 0.01) increased in expression. Half of the E-regulated probe sets were also regulated by c-myc. Genes involved in cell growth, cell proliferation, and cell survival were over-represented in the E-regulated geneset. Analysis of selected candidates has identified a nucleolar protein whose expression is correlated with c-myc expression in BC cell lines. These data indicate that a significant component of E-induced mitogenesis is mediated by c-myc and that selected c-myc target genes may be surrogate markers of c-myc expression in BC. JF - Advances in experimental medicine and biology SN - 0065-2598 EP - 451 TI - Identification of downstream targets of estrogen and c-myc in breast cancer cells. VL - 617 SP - 445 KW - breast KW - cancer KW - downstream KW - estrogen KW - target KW - thelist AU - Musgrove, EA AU - Sergio, CM AU - Anderson, LR AU - Inman, CK AU - McNeil, CM AU - Alles, MC AU - Gardiner-Garden, M AU - Ormandy, CJ AU - Butt, AJ AU - Sutherland, RL PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18497068 ER -