Reproductive and Hormonal Risk Factors for Ductal Carcinoma In situ of the Breast. Export

@article{citeulike:4563691, abstract = {One-fifth of all newly diagnosed breast cancer cases are ductal carcinoma in situ (DCIS), but little is known about DCIS risk factors. Recent studies suggest that some subtypes of DCIS (high grade or comedo) share histopathologic and epidemiologic characteristics with invasive disease, whereas others (medium or low grade or non-comedo) show different patterns. To investigate whether reproductive and hormonal risk factors differ among comedo and non-comedo types of DCIS and invasive breast cancer (IBC), we used a population-based case-control study of 1,808 invasive and 446 DCIS breast cancer cases and their age and race frequency-matched controls (1,564 invasive and 458 DCIS). Three or more full-term pregnancies showed a strong inverse association with comedo-type DCIS [odds ratio (OR), 0.53; 95\% confidence interval (95\% CI), 0.30-0.95] and a weaker inverse association for non-comedo DCIS (OR, 0.73; 95\% CI, 0.42-1.27). Several risk factors (age at first full-term pregnancy, breast-feeding, and age at menopause) showed similar associations for comedo-type DCIS and IBC but different associations for non-comedo DCIS. Ten or more years of oral contraceptive showed a positive association with comedo-type DCIS (OR, 1.31; 95\% CI, 0.70-2.47) and IBC (OR, 2.33; 95\% CI, 1.06-5.09) but an inverse association for non-comedo DCIS (OR, 0.51; 95\% CI, 0.25-1.04). Our results support the theory that comedo-type DCIS may share hormonal and reproductive risk factors with IBC, whereas the etiology of non-comedo DCIS deserves further investigation. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1507-14).}, author = {Phillips, L. S. and Millikan, R. C. and Schroeder, J. C. and Barnholtz-Sloan, J. S. and Levine, B. J.}, citeulike-article-id = {4563691}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1055-9965.EPI-08-0967}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19423528}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19423528}, doi = {10.1158/1055-9965.EPI-08-0967}, issn = {1055-9965}, journal = {Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, keywords = {breast, cancer, dcis, hormonal, reproductive, risk-factors, thelist}, month = {May}, number = {5}, pages = {1507--1514}, posted-at = {2009-05-20 20:42:14}, priority = {2}, title = {Reproductive and Hormonal Risk Factors for Ductal Carcinoma In situ of the Breast.}, url = {http://dx.doi.org/10.1158/1055-9965.EPI-08-0967}, volume = {18}, year = {2009} }

TY - JOUR ID - citeulike:4563691 L3 - citeulike-article-id:4563691 N2 - One-fifth of all newly diagnosed breast cancer cases are ductal carcinoma in situ (DCIS), but little is known about DCIS risk factors. Recent studies suggest that some subtypes of DCIS (high grade or comedo) share histopathologic and epidemiologic characteristics with invasive disease, whereas others (medium or low grade or non-comedo) show different patterns. To investigate whether reproductive and hormonal risk factors differ among comedo and non-comedo types of DCIS and invasive breast cancer (IBC), we used a population-based case-control study of 1,808 invasive and 446 DCIS breast cancer cases and their age and race frequency-matched controls (1,564 invasive and 458 DCIS). Three or more full-term pregnancies showed a strong inverse association with comedo-type DCIS [odds ratio (OR), 0.53; 95% confidence interval (95% CI), 0.30-0.95] and a weaker inverse association for non-comedo DCIS (OR, 0.73; 95% CI, 0.42-1.27). Several risk factors (age at first full-term pregnancy, breast-feeding, and age at menopause) showed similar associations for comedo-type DCIS and IBC but different associations for non-comedo DCIS. Ten or more years of oral contraceptive showed a positive association with comedo-type DCIS (OR, 1.31; 95% CI, 0.70-2.47) and IBC (OR, 2.33; 95% CI, 1.06-5.09) but an inverse association for non-comedo DCIS (OR, 0.51; 95% CI, 0.25-1.04). Our results support the theory that comedo-type DCIS may share hormonal and reproductive risk factors with IBC, whereas the etiology of non-comedo DCIS deserves further investigation. (Cancer Epidemiol Biomarkers Prev 2009;18(5):1507-14). IS - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology SN - 1055-9965 EP - 1514 TI - Reproductive and Hormonal Risk Factors for Ductal Carcinoma In situ of the Breast. VL - 18 SP - 1507 KW - breast KW - cancer KW - dcis KW - hormonal KW - reproductive KW - risk-factors KW - thelist AU - Phillips, LS AU - Millikan, RC AU - Schroeder, JC AU - Barnholtz-Sloan, JS AU - Levine, BJ PY - 2009/05// UR - http://dx.doi.org/10.1158/1055-9965.EPI-08-0967 ER -