Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. Export

@article{citeulike:4771310, abstract = {The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.}, author = {Deaglio, S. and Dwyer, K. M. and Gao, W. and Friedman, D. and Usheva, A. and Erat, A. and Chen, J. F. and Enjyoji, K. and Linden, J. and Oukka, M. and Kuchroo, V. K. and Strom, T. B. and Robson, S. C.}, citeulike-article-id = {4771310}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20062512}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17502665}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17502665}, day = {11}, doi = {10.1084/jem.20062512}, issn = {0022-1007}, journal = {The Journal of experimental medicine}, keywords = {adenosine, cd39, cd73, superlist, suppression, thelist, treg}, month = {June}, number = {6}, pages = {1257--1265}, posted-at = {2009-06-08 00:36:32}, priority = {2}, title = {Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.}, url = {http://dx.doi.org/10.1084/jem.20062512}, volume = {204}, year = {2007} }

TY - JOUR ID - citeulike:4771310 L3 - citeulike-article-id:4771310 N2 - The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation. IS - 6 JF - The Journal of experimental medicine SN - 0022-1007 EP - 1265 TI - Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. VL - 204 SP - 1257 KW - adenosine KW - cd39 KW - cd73 KW - superlist KW - suppression KW - thelist KW - treg AU - Deaglio, S AU - Dwyer, KM AU - Gao, W AU - Friedman, D AU - Usheva, A AU - Erat, A AU - Chen, JF AU - Enjyoji, K AU - Linden, J AU - Oukka, M AU - Kuchroo, VK AU - Strom, TB AU - Robson, SC PY - 2007/06/11/ UR - http://dx.doi.org/10.1084/jem.20062512 ER -