Risk of breast cancer according to the status of HER-2/neu oncogene amplification. Export

@article{citeulike:4885567, abstract = {We examined risk factors for breast cancer after subdividing cases based on the presence of HER-2/neu oncogene amplification in their tumors. Data were from the Carolina Breast Cancer Study, a population-based, case-control study of 577 invasive breast cancer patients, diagnosed during 1993-1996 and ages 20-74 years, and 790 controls frequency-matched on race and age. Information on breast cancer risk factors was obtained from structured personal interviews. About 20\% of paraffin-embedded tissues from the breast cancers of cases were identified as positive for HER-2/neu amplification (HER-2/neu+) by differential PCR. Early age at menarche, higher waist:hip ratio, and family history of breast or ovarian cancer were associated with elevated odds ratios (ORs) for both HER-2/neu+ and HER-2/neu- breast cancers. Breastfeeding for at least 1 year was inversely associated with HER-2/neu+ breast cancer [OR, 0.3; 95\% confidence interval (CI), 0.1-0.7] more so than HER-2/neu- breast cancer (OR, 0.8; 95\% CI, 0.5-1.2). Most of the remaining risk factors had ORs around 1.0 for both HER-2/neu+ and HER-2/neu- breast cancers, although a few exhibited possible associations with one disease subtype in analyses stratified by menopausal status. These study results suggest that most recognized breast cancer risk factors do not operate through HER-2/neu amplification in breast carcinogenesis. Differential effects of long-term breastfeeding by HER-2/neu amplification status have been observed in earlier studies and are provocative; however, the direction and magnitude of the associations have not been consistent.}, author = {Huang, W. Y. and Newman, B. and Millikan, R. C. and Conway, K. and Hulka, B. S. and Schell, M. J. and Liu, E. T.}, citeulike-article-id = {4885567}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10667465}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10667465}, issn = {1055-9965}, journal = {Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, keywords = {breast, cancer, her2, superlist, thelist}, month = {January}, number = {1}, pages = {65--71}, posted-at = {2009-06-18 00:40:40}, priority = {2}, title = {Risk of breast cancer according to the status of HER-2/neu oncogene amplification.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10667465}, volume = {9}, year = {2000} }

TY - JOUR ID - citeulike:4885567 L3 - citeulike-article-id:4885567 N2 - We examined risk factors for breast cancer after subdividing cases based on the presence of HER-2/neu oncogene amplification in their tumors. Data were from the Carolina Breast Cancer Study, a population-based, case-control study of 577 invasive breast cancer patients, diagnosed during 1993-1996 and ages 20-74 years, and 790 controls frequency-matched on race and age. Information on breast cancer risk factors was obtained from structured personal interviews. About 20% of paraffin-embedded tissues from the breast cancers of cases were identified as positive for HER-2/neu amplification (HER-2/neu+) by differential PCR. Early age at menarche, higher waist:hip ratio, and family history of breast or ovarian cancer were associated with elevated odds ratios (ORs) for both HER-2/neu+ and HER-2/neu- breast cancers. Breastfeeding for at least 1 year was inversely associated with HER-2/neu+ breast cancer [OR, 0.3; 95% confidence interval (CI), 0.1-0.7] more so than HER-2/neu- breast cancer (OR, 0.8; 95% CI, 0.5-1.2). Most of the remaining risk factors had ORs around 1.0 for both HER-2/neu+ and HER-2/neu- breast cancers, although a few exhibited possible associations with one disease subtype in analyses stratified by menopausal status. These study results suggest that most recognized breast cancer risk factors do not operate through HER-2/neu amplification in breast carcinogenesis. Differential effects of long-term breastfeeding by HER-2/neu amplification status have been observed in earlier studies and are provocative; however, the direction and magnitude of the associations have not been consistent. IS - 1 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology SN - 1055-9965 EP - 71 TI - Risk of breast cancer according to the status of HER-2/neu oncogene amplification. VL - 9 SP - 65 KW - breast KW - cancer KW - her2 KW - superlist KW - thelist AU - Huang, WY AU - Newman, B AU - Millikan, RC AU - Conway, K AU - Hulka, BS AU - Schell, MJ AU - Liu, ET PY - 2000/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/10667465 ER -