Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. Export

@article{citeulike:4911121, abstract = {Estrogens affect the development, maturation, and function of multiple organ systems, including the immune system. One of the main targets of estrogens in the immune system is the thymus, which undergoes atrophy and phenotypic alterations when exposed to elevated levels of estrogen. To determine how estrogens influence the thymus and affect T cell development, estrogen receptor alpha (ERalpha) knockout (ERKO) mice were examined. ERKO mice have significantly smaller thymi than their wild-type (WT) littermates. Construction of ER radiation bone marrow chimeras indicated that the smaller thymi were due to a lack of ERalpha in radiation-resistant tissues rather than hemopoietic elements. ERKO mice were also susceptible to estradiol-induced thymic atrophy, but the extent of their atrophy was less than what was seen in WT mice. The estradiol-treated ERKO mice failed, however, to manifest alterations in their thymic CD4/CD8 phenotypes compared with WT mice. Therefore, ERalpha is essential in nonhemopoietic cells to obtain a full-sized thymus, and ERalpha also mediates some of the response of the thymus to elevated estrogen levels. Finally, these results suggest that in addition to ERalpha, another receptor pathway is involved in estradiol-induced thymic atrophy.}, author = {Staples, J. E. and Gasiewicz, T. A. and Fiore, N. C. and Lubahn, D. B. and Korach, K. S. and Silverstone, A. E.}, citeulike-article-id = {4911121}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10510352}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10510352}, day = {15}, issn = {0022-1767}, journal = {Journal of immunology (Baltimore, Md. : 1950)}, keywords = {er, estrogen, receptor, superlist, thelist, thymus}, month = {October}, number = {8}, pages = {4168--4174}, posted-at = {2009-06-19 20:14:18}, priority = {2}, title = {Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10510352}, volume = {163}, year = {1999} }

TY - JOUR ID - citeulike:4911121 L3 - citeulike-article-id:4911121 N2 - Estrogens affect the development, maturation, and function of multiple organ systems, including the immune system. One of the main targets of estrogens in the immune system is the thymus, which undergoes atrophy and phenotypic alterations when exposed to elevated levels of estrogen. To determine how estrogens influence the thymus and affect T cell development, estrogen receptor alpha (ERalpha) knockout (ERKO) mice were examined. ERKO mice have significantly smaller thymi than their wild-type (WT) littermates. Construction of ER radiation bone marrow chimeras indicated that the smaller thymi were due to a lack of ERalpha in radiation-resistant tissues rather than hemopoietic elements. ERKO mice were also susceptible to estradiol-induced thymic atrophy, but the extent of their atrophy was less than what was seen in WT mice. The estradiol-treated ERKO mice failed, however, to manifest alterations in their thymic CD4/CD8 phenotypes compared with WT mice. Therefore, ERalpha is essential in nonhemopoietic cells to obtain a full-sized thymus, and ERalpha also mediates some of the response of the thymus to elevated estrogen levels. Finally, these results suggest that in addition to ERalpha, another receptor pathway is involved in estradiol-induced thymic atrophy. IS - 8 JF - Journal of immunology (Baltimore, Md. : 1950) SN - 0022-1767 EP - 4174 TI - Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. VL - 163 SP - 4168 KW - er KW - estrogen KW - receptor KW - superlist KW - thelist KW - thymus AU - Staples, JE AU - Gasiewicz, TA AU - Fiore, NC AU - Lubahn, DB AU - Korach, KS AU - Silverstone, AE PY - 1999/10/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10510352 ER -