Histopathology of BRCA1- and BRCA2-associated breast cancer Export

@article{citeulike:5230359, abstract = {Hereditary breast carcinomas that are attributable to BRCA1 / 2 mutations have their own morphological and immunohistochemical characteristics. BRCA1 -associated carcinomas are poorly differentiated infiltrating ductal carcinomas that frequently show morphological features of typical or atypical medullary carcinoma. BRCA2 -associated breast carcinomas tend to be of higher grade than sporadic age-matched controls. BRCA1  tumors have been found to be more frequently estrogen receptor- and progesterone receptor-negative, and p53-positive than are age-matched controls, whereas these differences are not usually found in BRCA2- associated tumors. In addition, BRCA1- and BRCA2- associated breast carcinomas show a low frequency of HER2 expression. Most BRCA1 breast carcinomas are characterized by the expression of basal (myoepithelial) markers, such as cytokeratin 5/6 and or P-cadherin. These features could be used to distinguish patients who are likely to carry a BRCA1 or BRCA2 germline mutation, thus indicating which gene should be screened for first in families with a high incidence of breast and ovarian cancer.}, author = {Honrado, E. and Benitez, J. and Palacios, J.}, citeulike-article-id = {5230359}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.critrevonc.2006.01.006}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1040842806000163}, doi = {10.1016/j.critrevonc.2006.01.006}, issn = {10408428}, journal = {Critical Reviews in Oncology/Hematology}, keywords = {breast, cancer, hereditary, histopathology, superlist, thelist}, month = {July}, number = {1}, pages = {27--39}, posted-at = {2009-07-22 18:46:00}, priority = {2}, title = {Histopathology of BRCA1- and BRCA2-associated breast cancer}, url = {http://dx.doi.org/10.1016/j.critrevonc.2006.01.006}, volume = {59}, year = {2006} }

TY - JOUR ID - citeulike:5230359 L3 - citeulike-article-id:5230359 N2 - Hereditary breast carcinomas that are attributable to BRCA1 / 2 mutations have their own morphological and immunohistochemical characteristics. BRCA1 -associated carcinomas are poorly differentiated infiltrating ductal carcinomas that frequently show morphological features of typical or atypical medullary carcinoma. BRCA2 -associated breast carcinomas tend to be of higher grade than sporadic age-matched controls. BRCA1  tumors have been found to be more frequently estrogen receptor- and progesterone receptor-negative, and p53-positive than are age-matched controls, whereas these differences are not usually found in BRCA2- associated tumors. In addition, BRCA1- and BRCA2- associated breast carcinomas show a low frequency of HER2 expression. Most BRCA1 breast carcinomas are characterized by the expression of basal (myoepithelial) markers, such as cytokeratin 5/6 and or P-cadherin. These features could be used to distinguish patients who are likely to carry a BRCA1 or BRCA2 germline mutation, thus indicating which gene should be screened for first in families with a high incidence of breast and ovarian cancer. IS - 1 JF - Critical Reviews in Oncology/Hematology SN - 10408428 EP - 39 TI - Histopathology of BRCA1- and BRCA2-associated breast cancer VL - 59 SP - 27 KW - breast KW - cancer KW - hereditary KW - histopathology KW - superlist KW - thelist AU - Honrado, E AU - Benitez, J AU - Palacios, J PY - 2006/07// UR - http://dx.doi.org/10.1016/j.critrevonc.2006.01.006 ER -