The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. Export

@article{citeulike:5241339, abstract = {PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify patients who are likely to carry germline mutations in BRCA1 and BRCA2. This study evaluates the immunohistochemical profiles of tumors arising in patients with mutations in these genes. MATERIALS AND METHODS: Samples of breast cancers obtained from the International Breast Cancer Linkage Consortium were characterized morphologically and immunohistochemically using antibodies to estrogen receptor, progesterone receptor, HER-2 (c-erbB-2 oncogene), and p53 protein. RESULTS: Breast cancers in patients with BRCA1 germline mutations are more often negative for estrogen receptor, progesterone receptor, and HER-2, and are more likely to be positive for p53 protein compared with controls. In contrast, BRCA2 tumors do not show a significant difference in the expression of any of these proteins compared with controls. CONCLUSION: BRCA1 has a distinctive morphology and immunohistochemical phenotype. The combined morphologic and immunohistochemical data can be used to predict the risk of a young patient harboring a germline mutation in BRCA1. The BRCA2 phenotype is currently not well defined.}, author = {Lakhani, S. R. and Van De Vijver, M. J. and Jacquemier, J. and Anderson, T. J. and Osin, P. P. and McGuffog, L. and Easton, D. F.}, citeulike-article-id = {5241339}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11981002}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11981002}, day = {1}, issn = {0732-183X}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, keywords = {brca1, brca2, breast, cancer, hereditary, superlist, thelist}, month = {May}, number = {9}, pages = {2310--2318}, posted-at = {2009-07-23 19:54:30}, priority = {2}, title = {The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11981002}, volume = {20}, year = {2002} }

TY - JOUR ID - citeulike:5241339 L3 - citeulike-article-id:5241339 N2 - PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify patients who are likely to carry germline mutations in BRCA1 and BRCA2. This study evaluates the immunohistochemical profiles of tumors arising in patients with mutations in these genes. MATERIALS AND METHODS: Samples of breast cancers obtained from the International Breast Cancer Linkage Consortium were characterized morphologically and immunohistochemically using antibodies to estrogen receptor, progesterone receptor, HER-2 (c-erbB-2 oncogene), and p53 protein. RESULTS: Breast cancers in patients with BRCA1 germline mutations are more often negative for estrogen receptor, progesterone receptor, and HER-2, and are more likely to be positive for p53 protein compared with controls. In contrast, BRCA2 tumors do not show a significant difference in the expression of any of these proteins compared with controls. CONCLUSION: BRCA1 has a distinctive morphology and immunohistochemical phenotype. The combined morphologic and immunohistochemical data can be used to predict the risk of a young patient harboring a germline mutation in BRCA1. The BRCA2 phenotype is currently not well defined. IS - 9 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology SN - 0732-183X EP - 2318 TI - The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. VL - 20 SP - 2310 KW - brca1 KW - brca2 KW - breast KW - cancer KW - hereditary KW - superlist KW - thelist AU - Lakhani, SR AU - Van De Vijver, MJ AU - Jacquemier, J AU - Anderson, TJ AU - Osin, PP AU - McGuffog, L AU - Easton, DF PY - 2002/05/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11981002 ER -