Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Export

@article{citeulike:5241345, abstract = {PURPOSE: BRCA1-related breast cancers are more frequently estrogen receptor (ER) negative than are either BRCA2-related or nonhereditary breast cancers. The relationship between ER status and other clinical features of hereditary breast cancers has not been well studied. EXPERIMENTAL DESIGN: ER status, grade, and histological tumor type were evaluated in 1131 women with invasive breast cancer, ascertained at 10 centers in North America. There were 208 BRCA1 mutation carriers, 88 BRCA2 carriers, and 804 women without a known mutation. We stratified the patients by mutation status, grade, age, and histological type and calculated the percentage of ER-positive tumors within each stratum. RESULTS: BRCA1 mutation carriers were more likely to have ER-negative breast cancers than were women in other groups, after adjustment for age, grade, and histological subtype (P < 0.001). Only 3.9\% of BRCA1-related breast cancers were ER-positive cancers occurring in women in their postmenopausal years. The direction and magnitude of the change in ER status with increasing age at diagnosis in BRCA1 carriers was significantly different from in BRCA2 carriers (P(intercept) = 0.0002, P(slope) = 0.04). Notably, changes in ER status with age at diagnosis for BRCA1 carriers and noncarriers were almost identical (P(slope) = 0.98). CONCLUSIONS: The strong relationship between the presence of a BRCA1 mutation and the ER-negative status of the breast cancers is neither a consequence of the young age at onset nor the high grade but is an intrinsic property of BRCA1-related cancers. The ER-negative status of these cancers may reflect the cell of origin of BRCA1-related cancers.}, author = {Foulkes, W. D. and Metcalfe, K. and Sun, P. and Hanna, W. M. and Lynch, H. T. and Ghadirian, P. and Tung, N. and Olopade, O. I. and Weber, B. L. and McLennan, J. and Olivotto, I. A. and B\'{e}gin, L. R. and Narod, S. A.}, citeulike-article-id = {5241345}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15041722}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15041722}, day = {15}, issn = {1078-0432}, journal = {Clinical cancer research : an official journal of the American Association for Cancer Research}, keywords = {brca1, brca2, breast, cancer, estrogen-receptor, hereditary, status, superlist, thelist}, month = {March}, number = {6}, pages = {2029--2034}, posted-at = {2009-07-23 19:55:36}, priority = {2}, title = {Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15041722}, volume = {10}, year = {2004} }

TY - JOUR ID - citeulike:5241345 L3 - citeulike-article-id:5241345 N2 - PURPOSE: BRCA1-related breast cancers are more frequently estrogen receptor (ER) negative than are either BRCA2-related or nonhereditary breast cancers. The relationship between ER status and other clinical features of hereditary breast cancers has not been well studied. EXPERIMENTAL DESIGN: ER status, grade, and histological tumor type were evaluated in 1131 women with invasive breast cancer, ascertained at 10 centers in North America. There were 208 BRCA1 mutation carriers, 88 BRCA2 carriers, and 804 women without a known mutation. We stratified the patients by mutation status, grade, age, and histological type and calculated the percentage of ER-positive tumors within each stratum. RESULTS: BRCA1 mutation carriers were more likely to have ER-negative breast cancers than were women in other groups, after adjustment for age, grade, and histological subtype (P < 0.001). Only 3.9% of BRCA1-related breast cancers were ER-positive cancers occurring in women in their postmenopausal years. The direction and magnitude of the change in ER status with increasing age at diagnosis in BRCA1 carriers was significantly different from in BRCA2 carriers (P(intercept) = 0.0002, P(slope) = 0.04). Notably, changes in ER status with age at diagnosis for BRCA1 carriers and noncarriers were almost identical (P(slope) = 0.98). CONCLUSIONS: The strong relationship between the presence of a BRCA1 mutation and the ER-negative status of the breast cancers is neither a consequence of the young age at onset nor the high grade but is an intrinsic property of BRCA1-related cancers. The ER-negative status of these cancers may reflect the cell of origin of BRCA1-related cancers. IS - 6 JF - Clinical cancer research : an official journal of the American Association for Cancer Research SN - 1078-0432 EP - 2034 TI - Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. VL - 10 SP - 2029 KW - brca1 KW - brca2 KW - breast KW - cancer KW - estrogen-receptor KW - hereditary KW - status KW - superlist KW - thelist AU - Foulkes, WD AU - Metcalfe, K AU - Sun, P AU - Hanna, WM AU - Lynch, HT AU - Ghadirian, P AU - Tung, N AU - Olopade, OI AU - Weber, BL AU - McLennan, J AU - Olivotto, IA AU - Bégin, LR AU - Narod, SA PY - 2004/03/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/15041722 ER -