An evolutionary perspective on the mechanisms of immunosenescence Export

@article{citeulike:5457169, abstract = {There is an accumulating body of evidence that a decline in immune function with age is common to most if not all vertebrates. For instance, age-associated thymic involution seems to occur in all species that possess a thymus, indicating that this process is evolutionary ancient and conserved. The precise mechanisms regulating immunosenescence remain to be resolved, but much of what we do know is consistent with modern evolutionary theory. In this review, we assess our current knowledge from an evolutionary perspective on the occurrence of immunosenescence, we show that life history trade-offs play a key role and we highlight the possible advantages of the age-related decline in thymic function.}, author = {Shanley, Daryl P. and Aw, Danielle and Manley, Nancy R. and Palmer, Donald B.}, citeulike-article-id = {5457169}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.it.2009.05.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1471490609001057}, doi = {10.1016/j.it.2009.05.001}, issn = {1471-4906}, journal = {Trends in Immunology}, keywords = {evolution, immunosenescence, perspective, review}, month = {July}, number = {7}, pages = {374--381}, posted-at = {2009-10-13 06:03:24}, priority = {2}, title = {An evolutionary perspective on the mechanisms of immunosenescence}, url = {http://dx.doi.org/10.1016/j.it.2009.05.001}, volume = {30}, year = {2009} }

TY - JOUR ID - citeulike:5457169 L3 - citeulike-article-id:5457169 N2 - There is an accumulating body of evidence that a decline in immune function with age is common to most if not all vertebrates. For instance, age-associated thymic involution seems to occur in all species that possess a thymus, indicating that this process is evolutionary ancient and conserved. The precise mechanisms regulating immunosenescence remain to be resolved, but much of what we do know is consistent with modern evolutionary theory. In this review, we assess our current knowledge from an evolutionary perspective on the occurrence of immunosenescence, we show that life history trade-offs play a key role and we highlight the possible advantages of the age-related decline in thymic function. IS - 7 JF - Trends in Immunology SN - 1471-4906 EP - 381 TI - An evolutionary perspective on the mechanisms of immunosenescence VL - 30 SP - 374 KW - evolution KW - immunosenescence KW - perspective KW - review AU - Shanley, Daryl AU - Aw, Danielle AU - Manley, Nancy AU - Palmer, Donald PY - 2009/07// UR - http://dx.doi.org/10.1016/j.it.2009.05.001 ER -