Chronic inflammation in benign prostatic hyperplasia: implications for therapy. Export

@article{citeulike:5655314, abstract = {Benign prostatic hyperplasia (BPH) is a common age related proliferative abnormality of the human prostate. Histological features demonstrate that the typical nodules of BPH are composed of stromal and epithelial cells that are proportionally different between nodules. BPH nodules frequently occur concurrently with chronic inflammatory infiltrates, mainly composed of chronically activated T cells and macrophages. Recent studies suggest that these inflammatory cells, immunity responses and their precursors play important roles in the pathogenesis of BPH. Clinical evidences also indicate that chronic inflammation correlates with clinical progression of BPH. Therefore, we hypothesize that BPH is an inflammatory disease. Reducing inflammation may play a crucial role in the treatment of BPH and finally lead to a better clinical outcome. If our hypotheses can be further supported with clinical trials it may change the approach of the medical management for BPH.}, author = {Wang, Long and Yang, Jin-rui R. and Yang, Luo-yan Y. and Liu, Zi-ting T.}, citeulike-article-id = {5655314}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mehy.2007.08.022}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17935901}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17935901}, doi = {10.1016/j.mehy.2007.08.022}, issn = {0306-9877}, journal = {Medical hypotheses}, keywords = {bph, inflammation, prostate}, number = {5}, pages = {1021--1023}, posted-at = {2009-08-26 22:50:05}, priority = {2}, title = {Chronic inflammation in benign prostatic hyperplasia: implications for therapy.}, url = {http://dx.doi.org/10.1016/j.mehy.2007.08.022}, volume = {70}, year = {2008} }

TY - JOUR ID - citeulike:5655314 L3 - citeulike-article-id:5655314 N2 - Benign prostatic hyperplasia (BPH) is a common age related proliferative abnormality of the human prostate. Histological features demonstrate that the typical nodules of BPH are composed of stromal and epithelial cells that are proportionally different between nodules. BPH nodules frequently occur concurrently with chronic inflammatory infiltrates, mainly composed of chronically activated T cells and macrophages. Recent studies suggest that these inflammatory cells, immunity responses and their precursors play important roles in the pathogenesis of BPH. Clinical evidences also indicate that chronic inflammation correlates with clinical progression of BPH. Therefore, we hypothesize that BPH is an inflammatory disease. Reducing inflammation may play a crucial role in the treatment of BPH and finally lead to a better clinical outcome. If our hypotheses can be further supported with clinical trials it may change the approach of the medical management for BPH. IS - 5 JF - Medical hypotheses SN - 0306-9877 EP - 1023 TI - Chronic inflammation in benign prostatic hyperplasia: implications for therapy. VL - 70 SP - 1021 KW - bph KW - inflammation KW - prostate AU - Wang, Long AU - Yang, Jin-rui AU - Yang, Luo-yan AU - Liu, Zi-ting PY - 2008/// UR - http://dx.doi.org/10.1016/j.mehy.2007.08.022 ER -