Differences in tumor regulatory T-cell localization and activation status impact patient outcome. Export

@article{citeulike:5909286, abstract = {The presence of regulatory T cells (Treg) has been described in a large panel of solid tumors. However, their impact on tumor progression differs according to the tumor type analyzed. We recently obtained evidence in breast carcinoma that Treg localized within lymphoid aggregates, but not in the tumor bed, have a negative impact on patients' survival. Moreover, we showed selective Treg recruitment through CCR4/CCL22 in the lymphoid aggregates upon contact with dendritic cells (DC), where they became strongly and selectively activated (ICOS(high)) and block conventional T-cell response. Here, we discuss the meaning and potential implication of these novel findings.}, author = {M\'{e}n\'{e}trier-Caux, Christine and Gobert, Michael and Caux, Christophe}, citeulike-article-id = {5909286}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-09-1642}, citeulike-linkout-1 = {http://cancerres.aacrjournals.org/content/69/20/7895.abstract}, citeulike-linkout-2 = {http://cancerres.aacrjournals.org/content/69/20/7895.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19808962}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19808962}, day = {15}, doi = {10.1158/0008-5472.CAN-09-1642}, issn = {1538-7445}, journal = {Cancer research}, keywords = {breast, cancer, localization, progression, treg, treg-bc}, month = {October}, number = {20}, pages = {7895--7898}, posted-at = {2009-10-08 12:46:22}, priority = {2}, title = {Differences in tumor regulatory T-cell localization and activation status impact patient outcome.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-09-1642}, volume = {69}, year = {2009} }

TY - JOUR ID - citeulike:5909286 L3 - citeulike-article-id:5909286 N2 - The presence of regulatory T cells (Treg) has been described in a large panel of solid tumors. However, their impact on tumor progression differs according to the tumor type analyzed. We recently obtained evidence in breast carcinoma that Treg localized within lymphoid aggregates, but not in the tumor bed, have a negative impact on patients' survival. Moreover, we showed selective Treg recruitment through CCR4/CCL22 in the lymphoid aggregates upon contact with dendritic cells (DC), where they became strongly and selectively activated (ICOS(high)) and block conventional T-cell response. Here, we discuss the meaning and potential implication of these novel findings. IS - 20 JF - Cancer research SN - 1538-7445 EP - 7898 TI - Differences in tumor regulatory T-cell localization and activation status impact patient outcome. VL - 69 SP - 7895 KW - breast KW - cancer KW - localization KW - progression KW - treg KW - treg-bc AU - Ménétrier-Caux, Christine AU - Gobert, Michael AU - Caux, Christophe PY - 2009/10/15/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-09-1642 ER -