Will telomere erosion lead to a loss of T-cell memory? Export

@article{citeulike:5932130, abstract = {Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.}, author = {Akbar, Arne N. and Beverley, Peter C. L. and Salmon, Mike}, citeulike-article-id = {5932130}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri1440}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nri1440}, day = {01}, doi = {10.1038/nri1440}, issn = {1474-1733}, journal = {Nature Reviews Immunology}, keywords = {immunosenescence, t-cell, telomere}, month = {September}, number = {9}, pages = {737--743}, posted-at = {2009-10-13 06:05:58}, priority = {2}, publisher = {Nature Publishing Group}, title = {Will telomere erosion lead to a loss of T-cell memory?}, url = {http://dx.doi.org/10.1038/nri1440}, volume = {4}, year = {2004} }

TY - JOUR ID - citeulike:5932130 L3 - citeulike-article-id:5932130 N2 - Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases. IS - 9 JF - Nature Reviews Immunology SN - 1474-1733 EP - 743 TI - Will telomere erosion lead to a loss of T-cell memory? PB - Nature Publishing Group VL - 4 SP - 737 KW - immunosenescence KW - t-cell KW - telomere AU - Akbar, Arne AU - Beverley, Peter AU - Salmon, Mike PY - 2004/09/01/ UR - http://dx.doi.org/10.1038/nri1440 ER -