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Confounder summary scores when comparing the effects of multiple drug exposures

by: Suzanne M. Cadarette, Joshua J. Gagne, Daniel H. Solomon, Jeffrey N. Katz, Til Stürmer
Pharmacoepidemiology and Drug Safety, Vol. 19, No. 1. (January 2010), pp. 2-9, doi:10.1002/pds.1845  Key: citeulike:9275204

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Abstract

With sufficient numbers of exposed and outcomes, either conventional multivariable, EPS or full cohort DRS may be used to adjust for confounding to compare the effects of multiple drug exposures. However, our data also suggest that unexposed cohort DRS may be problematic when background risks differ between referent and exposed groups. Further empirical and simulation studies will help to clarify the generalizability of our findings.


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