Zephyrus's okt3 [1 article]

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Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients.

The New England journal of medicine, Vol. 323, No. 25. (20 December 1990), pp. 1723-1728.

by L. J. Swinnen, M. R. Costanzo-Nordin, S. G. Fisher, et al.E. J. O'Sullivan, M. R. Johnson, A. L. Heroux, G. J. Dizikes, R. Pifarre, R. I. Fisher

posted to fisher immunosuppression immunosurveillance okt3 transplantation thelist superlist by Zephyrus on 2009-07-09 19:28:03

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Abstract

BACKGROUND. A sudden increase in the incidence of post-transplantation lymphoproliferative disorder among the patients in our cardiac-transplantation program was temporally related to introduction of the immunosuppressive drug OKT3. This monoclonal antibody has come to be widely used in recent years both to prevent and to treat rejection after cardiac transplantation. METHODS. In order to identify variables that predict the development of post-transplantation lymphoproliferative disorder, we analyzed retrospectively a series of 154 consecutive cardiac-transplant recipients at a single institution. Univariate analyses and ...

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Zephyrus's okt3 [1 article]

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