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Nat Rev Genet, Vol. 13, No. 12. (16 December 2012), pp. 867-877, doi:10.1038/nrg3322 Key: citeulike:11701177
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Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular
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