Wnt signalling: variety at the core. Export

@article{citeulike:1691080, abstract = {The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.}, address = {Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. s.p.hoppler@abdn.ac.uk}, author = {Hoppler, S. and Kavanagh, C. L.}, citeulike-article-id = {1691080}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/jcs.03363}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17251379}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17251379}, day = {1}, doi = {10.1242/jcs.03363}, issn = {0021-9533}, journal = {J Cell Sci}, keywords = {cancer, cell, development, review, signaling, stem, tcflef, wnt}, month = {February}, number = {Pt 3}, pages = {385--393}, posted-at = {2007-09-25 01:56:28}, priority = {4}, title = {Wnt signalling: variety at the core.}, url = {http://dx.doi.org/10.1242/jcs.03363}, volume = {120}, year = {2007} }

TY - JOUR ID - citeulike:1691080 L3 - citeulike-article-id:1691080 N2 - The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer. IS - Pt 3 JF - J Cell Sci SN - 0021-9533 AD - Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK. s.p.hoppler@abdn.ac.uk EP - 393 TI - Wnt signalling: variety at the core. VL - 120 SP - 385 KW - cancer KW - cell KW - development KW - review KW - signaling KW - stem KW - tcflef KW - wnt AU - Hoppler, S AU - Kavanagh, CL PY - 2007/02/01/ UR - http://dx.doi.org/10.1242/jcs.03363 ER -