Array comparative genomic hybridization and its applications in cancer - Nature Genetics Export

@article{citeulike:2057535, abstract = {Alteration in DNA copy number is one of the many ways in which gene expression and function may be modified. Some variations are found among normal individuals, others occur in the course of normal processes in some species and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur before or shortly after fertilization, and DNA dosage-alteration changes occurring in somatic cells are frequent contributors to cancer. Detecting these aberrations and interpreting them in the context of broader knowledge facilitates the identification of crucial genes and pathways involved in biological processes and disease. Over the past several years, array comparative genomic hybridization has proven its value for analyzing DNA copy-number variations. Here, we discuss the state of the art of array comparative genomic hybridization and its applications in cancer, emphasizing general concepts rather than specific results.}, author = {Pinkel, Daniel and Albertson, Donna G.}, citeulike-article-id = {2057535}, citeulike-linkout-0 = {http://www.nature.com/ng/journal/v37/n6s/full/ng1569.html}, journal = {Nature Genetics 37, S11 - S17 (2005)}, keywords = {application, cancer, cgh, clinical, review}, pages = {S11--S17}, posted-at = {2007-12-04 16:51:55}, priority = {0}, title = {Array comparative genomic hybridization and its applications in cancer - Nature Genetics}, url = {http://www.nature.com/ng/journal/v37/n6s/full/ng1569.html}, volume = {37}, year = {2005} }

TY - JOUR ID - citeulike:2057535 L3 - citeulike-article-id:2057535 N2 - Alteration in DNA copy number is one of the many ways in which gene expression and function may be modified. Some variations are found among normal individuals, others occur in the course of normal processes in some species and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur before or shortly after fertilization, and DNA dosage-alteration changes occurring in somatic cells are frequent contributors to cancer. Detecting these aberrations and interpreting them in the context of broader knowledge facilitates the identification of crucial genes and pathways involved in biological processes and disease. Over the past several years, array comparative genomic hybridization has proven its value for analyzing DNA copy-number variations. Here, we discuss the state of the art of array comparative genomic hybridization and its applications in cancer, emphasizing general concepts rather than specific results. JF - Nature Genetics 37, S11 - S17 (2005) EP - S17 TI - Array comparative genomic hybridization and its applications in cancer - Nature Genetics VL - 37 SP - S11 KW - application KW - cancer KW - cgh KW - clinical KW - review AU - Pinkel, Daniel AU - Albertson, Donna PY - 2005/// UR - http://www.nature.com/ng/journal/v37/n6s/full/ng1569.html ER -