Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Export

@article{citeulike:226986, abstract = {Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated fibroblasts (CAFs) extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammary fibroblasts derived from the same patients. The CAFs, which exhibit the traits of myofibroblasts, play a central role in promoting the growth of tumor cells through their ability to secrete stromal cell-derived factor 1 (SDF-1); CAFs promote angiogenesis by recruiting endothelial progenitor cells (EPCs) into carcinomas, an effect mediated in part by SDF-1. CAF-secreted SDF-1 also stimulates tumor growth directly, acting through the cognate receptor, CXCR4, which is expressed by carcinoma cells. Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1.}, address = {Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.}, author = {Orimo, A. and Gupta, P. B. and Sgroi, D. C. and Arenzana-Seisdedos, F. and Delaunay, T. and Naeem, R. and Carey, V. J. and Richardson, A. L. and Weinberg, R. A.}, citeulike-article-id = {226986}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2005.02.034}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15882617}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15882617}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSN-4G3JX14-5/2/31e41a05172331b919a6bb39a58c34a1}, day = {6}, doi = {10.1016/j.cell.2005.02.034}, issn = {0092-8674}, journal = {Cell}, keywords = {breast, caf, cancer, culture, cxcr4, invasion, sdf1}, month = {May}, number = {3}, pages = {335--348}, posted-at = {2008-01-23 23:58:51}, priority = {2}, title = {Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.}, url = {http://dx.doi.org/10.1016/j.cell.2005.02.034}, volume = {121}, year = {2005} }

TY - JOUR ID - citeulike:226986 L3 - citeulike-article-id:226986 N2 - Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated fibroblasts (CAFs) extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammary fibroblasts derived from the same patients. The CAFs, which exhibit the traits of myofibroblasts, play a central role in promoting the growth of tumor cells through their ability to secrete stromal cell-derived factor 1 (SDF-1); CAFs promote angiogenesis by recruiting endothelial progenitor cells (EPCs) into carcinomas, an effect mediated in part by SDF-1. CAF-secreted SDF-1 also stimulates tumor growth directly, acting through the cognate receptor, CXCR4, which is expressed by carcinoma cells. Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1. IS - 3 JF - Cell SN - 0092-8674 AD - Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. EP - 348 TI - Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. VL - 121 SP - 335 KW - breast KW - caf KW - cancer KW - culture KW - cxcr4 KW - invasion KW - sdf1 AU - Orimo, A AU - Gupta, PB AU - Sgroi, DC AU - Arenzana-Seisdedos, F AU - Delaunay, T AU - Naeem, R AU - Carey, VJ AU - Richardson, AL AU - Weinberg, RA PY - 2005/05/06/ UR - http://dx.doi.org/10.1016/j.cell.2005.02.034 ER -