Molecular biology of breast metastasis: Clinical implications of experimental studies on metastatic inefficiency Export

@article{citeulike:2321024, abstract = {Recent technological advances have led to an increasing ability to detect isolated tumour cells and groups of tumour cells in patients' blood, lymph nodes or bone marrow. However, the clinical significance of these cells is unclear. Should they be considered as evidence of metastasis, necessitating aggressive treatment, or are they in some cases unrelated to clinical outcome? Quantitative experimental studies on the basic biology of metastatic inefficiency are providing clues that may help in understanding the significance of these cells. This understanding will be of use in guiding clinical studies to assess the significance of isolated tumour cells and micrometastases in cancer patients.}, author = {Chambers, Ann F. and Naumov, George N. and Vantyghem, Sharon A. and Tuck, Alan B.}, citeulike-article-id = {2321024}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/bcr86}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11178191}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11178191}, doi = {10.1186/bcr86}, journal = {Breast Cancer Res}, keywords = {background, biology, breat, cancer, metastasis, microenvironment, molecular, qe, reference}, number = {6}, pages = {400--407}, posted-at = {2008-02-02 00:11:17}, priority = {2}, title = {Molecular biology of breast metastasis: Clinical implications of experimental studies on metastatic inefficiency}, url = {http://dx.doi.org/10.1186/bcr86}, volume = {2}, year = {2000} }

TY - JOUR ID - citeulike:2321024 L3 - citeulike-article-id:2321024 N2 - Recent technological advances have led to an increasing ability to detect isolated tumour cells and groups of tumour cells in patients' blood, lymph nodes or bone marrow. However, the clinical significance of these cells is unclear. Should they be considered as evidence of metastasis, necessitating aggressive treatment, or are they in some cases unrelated to clinical outcome? Quantitative experimental studies on the basic biology of metastatic inefficiency are providing clues that may help in understanding the significance of these cells. This understanding will be of use in guiding clinical studies to assess the significance of isolated tumour cells and micrometastases in cancer patients. IS - 6 JF - Breast Cancer Res EP - 407 TI - Molecular biology of breast metastasis: Clinical implications of experimental studies on metastatic inefficiency VL - 2 SP - 400 KW - background KW - biology KW - breat KW - cancer KW - metastasis KW - microenvironment KW - molecular KW - qe KW - reference AU - Chambers, Ann AU - Naumov, George AU - Vantyghem, Sharon AU - Tuck, Alan PY - 2000/// UR - http://dx.doi.org/10.1186/bcr86 ER -