Oncogene - Abstract of article: Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma Export

@article{citeulike:2336908, abstract = {Genomes of solid tumors are characterized by gains and losses of regions, which may contribute to tumorigenesis by altering gene expression. Often the aberrations are extensive, encompassing whole chromosome arms, which makes identification of candidate genes in these regions difficult. Here, we focused on narrow regions of gene amplification to facilitate identification of genetic pathways important in oral squamous cell carcinoma (SCC) development. We used array comparative genomic hybridization (array CGH) to define minimum common amplified regions and then used expression analysis to identify candidate driver genes in amplicons that spanned <3 Mb. We found genes involved in integrin signaling (TLN1), survival (YAP1, BIRC2), and adhesion and migration (TLN1, LAMA3, MMP7), as well as members of the hedgehog (GLI2) and notch (JAG1, RBPSUH, FJX1) pathways to be amplified and overexpressed. Deregulation of these and other members of the hedgehog and notch pathways (HHIP, SMO, DLL1, NOTCH4) implicates deregulation of developmental and differentiation pathways, cell fate misspecification, in oral SCC development}, author = {Snijders, A. M. and Schmidt, B. L. and Fridlyand, J. and Dekker, N. and Pinkel, D. and Jordan, R. C. and Albertson, D. G.}, citeulike-article-id = {2336908}, citeulike-linkout-0 = {https://vpn.ucsf.edu/onc/journal/v24/n26/abs/,DanaInfo=www.nature.com+1208601a.html}, day = {16}, institution = {Cancer Research Institute, University of California San Francisco}, journal = {Oncogene}, keywords = {amplicons, amplification, array, cgh, deletion, oral, qe, scc}, month = {June}, number = {26}, pages = {4232--4242}, posted-at = {2008-02-05 19:48:00}, priority = {2}, publisher = {Nature publishing group}, title = {Oncogene - Abstract of article: Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma}, url = {https://vpn.ucsf.edu/onc/journal/v24/n26/abs/,DanaInfo=www.nature.com+1208601a.html}, volume = {24}, year = {2005} }

TY - JOUR ID - citeulike:2336908 L3 - citeulike-article-id:2336908 N2 - Genomes of solid tumors are characterized by gains and losses of regions, which may contribute to tumorigenesis by altering gene expression. Often the aberrations are extensive, encompassing whole chromosome arms, which makes identification of candidate genes in these regions difficult. Here, we focused on narrow regions of gene amplification to facilitate identification of genetic pathways important in oral squamous cell carcinoma (SCC) development. We used array comparative genomic hybridization (array CGH) to define minimum common amplified regions and then used expression analysis to identify candidate driver genes in amplicons that spanned <3 Mb. We found genes involved in integrin signaling (TLN1), survival (YAP1, BIRC2), and adhesion and migration (TLN1, LAMA3, MMP7), as well as members of the hedgehog (GLI2) and notch (JAG1, RBPSUH, FJX1) pathways to be amplified and overexpressed. Deregulation of these and other members of the hedgehog and notch pathways (HHIP, SMO, DLL1, NOTCH4) implicates deregulation of developmental and differentiation pathways, cell fate misspecification, in oral SCC development IS - 26 JF - Oncogene EP - 4242 TI - Oncogene - Abstract of article: Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma PB - Nature publishing group VL - 24 SP - 4232 KW - amplicons KW - amplification KW - array KW - cgh KW - deletion KW - oral KW - qe KW - scc AU - Snijders, AM AU - Schmidt, BL AU - Fridlyand, J AU - Dekker, N AU - Pinkel, D AU - Jordan, RC AU - Albertson, DG PY - 2005/06/16/ UR - https://vpn.ucsf.edu/onc/journal/v24/n26/abs/,DanaInfo=www.nature.com+1208601a.html ER -