Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum Export

@article{citeulike:1642760, abstract = {Chemotaxis, or cell migration guided by chemical cues, is critical for a multitude of biological processes in a diverse array of organisms. Dictyostelium discoideum amoebae rely on chemotaxis to find food and to survive starvation conditions, and we have taken advantage of this system to study the molecular regulation of this vital cell behavior. Previous work has identified phosphoinositide signaling as one mechanism which may contribute to directional sensing and actin polymerization during chemotaxis; a mechanism which is conserved in mammalian neutrophils. In this review, we will discuss recent data on genes and pathways governing directional sensing and actin polymerization, with a particular emphasis on contributions from our laboratory.}, author = {Willard, Stacey S. and Devreotes, Peter N.}, booktitle = {A special issue dedicated to Guenter Gerisch on the occasion of his 75th birthday}, citeulike-article-id = {1642760}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ejcb.2006.06.003}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B7GJ2-4KV4MJR-1/2/39affd35fe451800073d9eb698c24dfa}, day = {27}, doi = {10.1016/j.ejcb.2006.06.003}, journal = {European Journal of Cell Biology}, keywords = {amoeba, chemotaxis, gpcr, odorant, smell}, month = {September}, number = {9-10}, pages = {897--904}, posted-at = {2007-09-10 19:51:21}, priority = {2}, title = {Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum}, url = {http://dx.doi.org/10.1016/j.ejcb.2006.06.003}, volume = {85}, year = {2006} }

TY - JOUR ID - citeulike:1642760 L3 - citeulike-article-id:1642760 N2 - Chemotaxis, or cell migration guided by chemical cues, is critical for a multitude of biological processes in a diverse array of organisms. Dictyostelium discoideum amoebae rely on chemotaxis to find food and to survive starvation conditions, and we have taken advantage of this system to study the molecular regulation of this vital cell behavior. Previous work has identified phosphoinositide signaling as one mechanism which may contribute to directional sensing and actin polymerization during chemotaxis; a mechanism which is conserved in mammalian neutrophils. In this review, we will discuss recent data on genes and pathways governing directional sensing and actin polymerization, with a particular emphasis on contributions from our laboratory. IS - 9-10 JF - European Journal of Cell Biology EP - 904 TI - Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum VL - 85 T2 - A special issue dedicated to Guenter Gerisch on the occasion of his 75th birthday SP - 897 KW - amoeba KW - chemotaxis KW - gpcr KW - odorant KW - smell AU - Willard, Stacey AU - Devreotes, Peter PY - 2006/09/27/ UR - http://dx.doi.org/10.1016/j.ejcb.2006.06.003 ER -