High Species Variation within the Repertoire of Trace Amine Receptors Export

@article{citeulike:1690186, abstract = {Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.}, author = {Gloriam, D. E. and Bjarnadottir, T. K. and Schioth, H. B. and Fredriksson, R.}, citeulike-article-id = {1690186}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1196/annals.1327.052}, citeulike-linkout-1 = {http://dx.doi.org/10.1196/annals.1327.052}, doi = {10.1196/annals.1327.052}, journal = {Annals of the New York Academy of Sciences}, keywords = {amine, ciona, danio, elegans, genome, gpcr, human, insect, olfactory, receptors}, number = {1}, pages = {323--327}, posted-at = {2007-09-24 19:59:06}, priority = {2}, title = {High Species Variation within the Repertoire of Trace Amine Receptors}, url = {http://dx.doi.org/10.1196/annals.1327.052}, volume = {1040}, year = {2005} }

TY - JOUR ID - citeulike:1690186 L3 - citeulike-article-id:1690186 N2 - Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages. IS - 1 JF - Annals of the New York Academy of Sciences EP - 327 TI - High Species Variation within the Repertoire of Trace Amine Receptors VL - 1040 SP - 323 KW - amine KW - ciona KW - danio KW - elegans KW - genome KW - gpcr KW - human KW - insect KW - olfactory KW - receptors AU - Gloriam, DE AU - Bjarnadottir, TK AU - Schioth, HB AU - Fredriksson, R PY - 2005/// UR - http://dx.doi.org/10.1196/annals.1327.052 ER -