A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination Export

@article{citeulike:3051927, abstract = {The Tbx1 gene is a transcriptional regulator involved in the DiGeorge syndrome, which affects normal facial and tooth development. Several clinical reports point to a common enamel defect in the teeth of patients with DiGeorge syndrome. Here, we have analyzed the expression, regulation, and function of Tbx1 during mouse molar development. Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with proliferative events. Tbx1 expression in epithelium requires mesenchyme-derived signals: dental mesenchyme induces expression of Tbx1 in recombined dental and non-dental epithelia. Bead implantation experiments show that FGF molecules are able to maintain epithelial Tbx1 expression during odontogenesis. Expression of Tbx1 in dental epithelium of FGF receptor 2b-/- mutant mice is downregulated, showing a genetic link between FGF signaling and Tbx1 in teeth. Forced expression of Tbx1 in dental explants activates amelogenin expression. These results indicate that Tbx1 expression in developing teeth is under control of FGF signaling and correlates with determination of the ameloblast lineage.}, author = {Mitsiadis, Thimios A. and Tucker, Abigail S. and De Bari, Cosimo and Cobourne, Martyn T. and Rice, David P.}, citeulike-article-id = {3051927}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ydbio.2008.04.006}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WDG-4S98V18-2/1/ce7302ed10e45e111c6ac746873fd809}, day = {1}, doi = {10.1016/j.ydbio.2008.04.006}, journal = {Developmental Biology}, keywords = {ameloblast, bone, expression, fgf, gene, signaling, tbx1, teeth}, month = {August}, number = {1}, pages = {39--48}, posted-at = {2008-07-28 16:03:26}, priority = {2}, title = {A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination}, url = {http://dx.doi.org/10.1016/j.ydbio.2008.04.006}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:3051927 L3 - citeulike-article-id:3051927 N2 - The Tbx1 gene is a transcriptional regulator involved in the DiGeorge syndrome, which affects normal facial and tooth development. Several clinical reports point to a common enamel defect in the teeth of patients with DiGeorge syndrome. Here, we have analyzed the expression, regulation, and function of Tbx1 during mouse molar development. Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with proliferative events. Tbx1 expression in epithelium requires mesenchyme-derived signals: dental mesenchyme induces expression of Tbx1 in recombined dental and non-dental epithelia. Bead implantation experiments show that FGF molecules are able to maintain epithelial Tbx1 expression during odontogenesis. Expression of Tbx1 in dental epithelium of FGF receptor 2b-/- mutant mice is downregulated, showing a genetic link between FGF signaling and Tbx1 in teeth. Forced expression of Tbx1 in dental explants activates amelogenin expression. These results indicate that Tbx1 expression in developing teeth is under control of FGF signaling and correlates with determination of the ameloblast lineage. IS - 1 JF - Developmental Biology EP - 48 TI - A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination VL - 320 SP - 39 KW - ameloblast KW - bone KW - expression KW - fgf KW - gene KW - signaling KW - tbx1 KW - teeth AU - Mitsiadis, Thimios AU - Tucker, Abigail AU - De Bari, Cosimo AU - Cobourne, Martyn AU - Rice, David PY - 2008/08/01/ UR - http://dx.doi.org/10.1016/j.ydbio.2008.04.006 ER -