Persistent default-mode network connectivity during light sedation.

@article{citeulike:2387231, abstract = {The default-mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting-state, is attenuated during cognitively demanding, externally-cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process episodic memories and semantic knowledge integral to internally-generated mental activity. Here, we compare default-mode functional connectivity in the same group of subjects during rest and conscious sedation with midazolam, a state characterized by anterograde amnesia and a reduced level of consciousness. Although the DMN showed functional connectivity during both rest and conscious sedation, a direct comparison found that there was significantly reduced functional connectivity in the posterior cingulate cortex during conscious sedation. These results confirm that low-frequency oscillations in the DMN persist and remain highly correlated even at reduced levels of consciousness. We hypothesize that focal reductions in DMN connectivity, as shown here in the posterior cingulate cortex, may represent a stable correlate of reduced consciousness. Hum Brain Mapp, 2008. (c) 2008 Wiley-Liss, Inc.}, address = {Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.}, author = {Greicius, Michael D D. and Kiviniemi, Vesa and Tervonen, Osmo and Vainionp\"{a}\"{a}, Vilho and Alahuhta, Seppo and Reiss, Allan L L. and Menon, Vinod }, citeulike-article-id = {2387231}, doi = {10.1002/hbm.20537}, issn = {1065-9471}, journal = {Hum Brain Mapp}, keywords = {jc-hbm}, month = {January}, posted-at = {2008-04-22 03:11:25}, priority = {2}, title = {Persistent default-mode network connectivity during light sedation.}, url = {http://dx.doi.org/10.1002/hbm.20537}, year = {2008} }

TY - JOUR ID - citeulike:2387231 L3 - citeulike-article-id:2387231 TI - Persistent default-mode network connectivity during light sedation. JF - Hum Brain Mapp AD - Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California. SN - 1065-9471 N2 - The default-mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting-state, is attenuated during cognitively demanding, externally-cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process episodic memories and semantic knowledge integral to internally-generated mental activity. Here, we compare default-mode functional connectivity in the same group of subjects during rest and conscious sedation with midazolam, a state characterized by anterograde amnesia and a reduced level of consciousness. Although the DMN showed functional connectivity during both rest and conscious sedation, a direct comparison found that there was significantly reduced functional connectivity in the posterior cingulate cortex during conscious sedation. These results confirm that low-frequency oscillations in the DMN persist and remain highly correlated even at reduced levels of consciousness. We hypothesize that focal reductions in DMN connectivity, as shown here in the posterior cingulate cortex, may represent a stable correlate of reduced consciousness. Hum Brain Mapp, 2008. (c) 2008 Wiley-Liss, Inc. KW - jc-hbm AU - Greicius, Michael D AU - Kiviniemi, Vesa AU - Tervonen, Osmo AU - Vainionpää, Vilho AU - Alahuhta, Seppo AU - Reiss, Allan L AU - Menon, Vinod PY - 2008/01/24/ UR - http://dx.doi.org/10.1002/hbm.20537 ER -