Elevated donor troponin levels are associated with a lower frequency of allograft vasculopathy. Export

@article{citeulike:758708, abstract = {BACKGROUND: Cardiac allograft vasculopathy (CAV) is considered a major cause of morbidity and mortality in transplant recipients and may reflect immune-mediated endothelial injury in response to the donor heart. Elevated troponin levels in the donor serum might provide a marker for this phenomenon; therefore, we evaluated the relationship of donor troponin levels to the development of CAV. METHODS: A retrospective analysis of troponin levels was undertaken from cardiac donor patients, and transplant recipients were monitored for the development of vasculopathy by angiography (N = 171). RESULTS: Angiographically significant CAV developed in 6\% of transplantation patients and troponin levels were inversely related to the severity of CAV. CONCLUSIONS: Elevated donor troponin levels are not associated with the development of CAV but rather with a significantly reduced long-term risk of developing CAV, suggesting a possible protective effect of donor released protein.}, address = {Mayo Medical Center, Rochester, Minnesota, USA.}, author = {Miller, W. L. and Edwards, B. S. and Kremers, W. K. and Kushwaha, S. S. and McGregor, C. G. and Daly, R. C. and Jaffe, A. S.}, citeulike-article-id = {758708}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.healun.2005.05.021}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16364852}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16364852}, doi = {10.1016/j.healun.2005.05.021}, issn = {1557-3117}, journal = {J Heart Lung Transplant}, keywords = {donor, heart}, month = {December}, number = {12}, pages = {2075--2078}, posted-at = {2006-07-14 10:47:48}, priority = {2}, title = {Elevated donor troponin levels are associated with a lower frequency of allograft vasculopathy.}, url = {http://dx.doi.org/10.1016/j.healun.2005.05.021}, volume = {24}, year = {2005} }

TY - JOUR ID - citeulike:758708 L3 - citeulike-article-id:758708 N2 - BACKGROUND: Cardiac allograft vasculopathy (CAV) is considered a major cause of morbidity and mortality in transplant recipients and may reflect immune-mediated endothelial injury in response to the donor heart. Elevated troponin levels in the donor serum might provide a marker for this phenomenon; therefore, we evaluated the relationship of donor troponin levels to the development of CAV. METHODS: A retrospective analysis of troponin levels was undertaken from cardiac donor patients, and transplant recipients were monitored for the development of vasculopathy by angiography (N = 171). RESULTS: Angiographically significant CAV developed in 6% of transplantation patients and troponin levels were inversely related to the severity of CAV. CONCLUSIONS: Elevated donor troponin levels are not associated with the development of CAV but rather with a significantly reduced long-term risk of developing CAV, suggesting a possible protective effect of donor released protein. IS - 12 JF - J Heart Lung Transplant SN - 1557-3117 AD - Mayo Medical Center, Rochester, Minnesota, USA. EP - 2078 TI - Elevated donor troponin levels are associated with a lower frequency of allograft vasculopathy. VL - 24 SP - 2075 KW - donor KW - heart AU - Miller, WL AU - Edwards, BS AU - Kremers, WK AU - Kushwaha, SS AU - McGregor, CG AU - Daly, RC AU - Jaffe, AS PY - 2005/12// UR - http://dx.doi.org/10.1016/j.healun.2005.05.021 ER -