Cooperation, virulence and siderophore production in bacterial parasites. Export

@article{citeulike:1206440, abstract = {Kin selection theory predicts that the damage to a host resulting from parasite infection (parasite virulence) will be negatively correlated to the relatedness between parasites within the host. This occurs because a lower relatedness leads to greater competition for host resources, which favours rapid growth to achieve greater relative success within the host, and that higher parasite growth rate leads to higher virulence. We show that a biological feature of bacterial infections can lead to the opposite prediction: a positive correlation between relatedness and virulence. This occurs because a high relatedness can favour greater (cooperative) production of molecules that scavenge iron (siderophores), which results in higher growth rates and virulence. More generally, the same underlying idea can predict a positive relationship between relatedness and virulence in any case where parasites can cooperate to increase their growth rate; other examples include immune suppression and the production of biofilms to aid colonization.}, address = {Institute of Cell, Animal and Population Biology, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK. stu.west@ed.ac.uk}, author = {West, S. A. and Buckling, A.}, citeulike-article-id = {1206440}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rspb.2002.2209}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12590769}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12590769}, day = {7}, doi = {10.1098/rspb.2002.2209}, issn = {0962-8452}, journal = {Proc Biol Sci}, keywords = {bacteria, cooperation, evolution}, month = {January}, number = {1510}, pages = {37--44}, posted-at = {2007-04-04 17:59:35}, priority = {2}, title = {Cooperation, virulence and siderophore production in bacterial parasites.}, url = {http://dx.doi.org/10.1098/rspb.2002.2209}, volume = {270}, year = {2003} }

TY - JOUR ID - citeulike:1206440 L3 - citeulike-article-id:1206440 N2 - Kin selection theory predicts that the damage to a host resulting from parasite infection (parasite virulence) will be negatively correlated to the relatedness between parasites within the host. This occurs because a lower relatedness leads to greater competition for host resources, which favours rapid growth to achieve greater relative success within the host, and that higher parasite growth rate leads to higher virulence. We show that a biological feature of bacterial infections can lead to the opposite prediction: a positive correlation between relatedness and virulence. This occurs because a high relatedness can favour greater (cooperative) production of molecules that scavenge iron (siderophores), which results in higher growth rates and virulence. More generally, the same underlying idea can predict a positive relationship between relatedness and virulence in any case where parasites can cooperate to increase their growth rate; other examples include immune suppression and the production of biofilms to aid colonization. IS - 1510 JF - Proc Biol Sci SN - 0962-8452 AD - Institute of Cell, Animal and Population Biology, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK. stu.west@ed.ac.uk EP - 44 TI - Cooperation, virulence and siderophore production in bacterial parasites. VL - 270 SP - 37 KW - bacteria KW - cooperation KW - evolution AU - West, SA AU - Buckling, A PY - 2003/01/07/ UR - http://dx.doi.org/10.1098/rspb.2002.2209 ER -