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Room temperature stable 3-lithiothiophene: a facile synthesis of 3-functional thiophenes

by: Xiaoming Wu, Tian-An Chen, Lishan Zhu, Reuben D. Rieke
Tetrahedron Letters, Vol. 35, No. 22. (May 1994), pp. 3673-3674, doi:10.1016/s0040-4039(00)73068-1  Key: citeulike:11893438

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Abstract

3-Functionalized thiophenes were readily prepared by reacting electrophiles with 3-lithiothiophene at room temperature. 3-Lithiothiophene was found to be stable in hexane at room temperature. Reactions of 3-lithiothiophene with different electrophiles at room temperature in hexane provide a convinient route to 3-substituted thiophenes:


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