Action potential initiation and backpropagation in neurons of the mammalian CNS Export

@article{citeulike:1692977, abstract = {Most neurons in the mammalian CNS encode and transmit information via action potentials. Knowledge of where these electrical events are initiated and how they propagate within neurons is therefore fundamental to an understanding of neuronal function. While work from the 1950s suggested that action potentials are initiated in the axon, many subsequent investigations have suggested that action potentials can also be initiated in the dendrites. Recently, experiments using simultaneous patch-pipette recordings from different locations on the same neuron have been used to address this issue directly. These studies show that the site of action potential initiation is in the axon, even when synaptic activation is powerful enough to elicit dendritic electrogenesis. Furthermore, these and other studies also show that following initiation, action potentials actively backpropagate into the dendrites of many neuronal types, providing a retrograde signal of neuronal output to the dendritic tree.}, author = {Stuart, Greg and Spruston, Nelson and Sakmann, Bert and Hausser, Michael}, citeulike-article-id = {1692977}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0166-2236(96)10075-8}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0166-2236(96)10075-8}, citeulike-linkout-2 = {http://www.sciencedirect.com/science/article/B6T0V-3RSNK05-9/2/1c1ac67919206a9bf9c6b8e7819bd80e}, day = {19}, doi = {10.1016/S0166-2236(96)10075-8}, journal = {Trends in Neurosciences}, keywords = {active}, month = {February}, number = {3}, pages = {125--131}, posted-at = {2008-09-05 16:04:01}, priority = {2}, title = {Action potential initiation and backpropagation in neurons of the mammalian CNS}, url = {http://dx.doi.org/10.1016/S0166-2236(96)10075-8}, volume = {20}, year = {1997} }

TY - JOUR ID - citeulike:1692977 L3 - citeulike-article-id:1692977 N2 - Most neurons in the mammalian CNS encode and transmit information via action potentials. Knowledge of where these electrical events are initiated and how they propagate within neurons is therefore fundamental to an understanding of neuronal function. While work from the 1950s suggested that action potentials are initiated in the axon, many subsequent investigations have suggested that action potentials can also be initiated in the dendrites. Recently, experiments using simultaneous patch-pipette recordings from different locations on the same neuron have been used to address this issue directly. These studies show that the site of action potential initiation is in the axon, even when synaptic activation is powerful enough to elicit dendritic electrogenesis. Furthermore, these and other studies also show that following initiation, action potentials actively backpropagate into the dendrites of many neuronal types, providing a retrograde signal of neuronal output to the dendritic tree. IS - 3 JF - Trends in Neurosciences EP - 131 TI - Action potential initiation and backpropagation in neurons of the mammalian CNS VL - 20 SP - 125 KW - active AU - Stuart, Greg AU - Spruston, Nelson AU - Sakmann, Bert AU - Hausser, Michael PY - 1997/02/19/ UR - http://dx.doi.org/10.1016/S0166-2236(96)10075-8 ER -