Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation. Export

@article{citeulike:5972857, abstract = {The process of segmentation in vertebrates is described by a clock and wavefront model consisting of a Notch signal and an fibroblast growth factor-8 (FGF8) gradient, respectively. To further investigate the segmentation process, we screened gene expression profiles for downstream targets of the segmentation clock. The Rnd1 and Rnd3 GTP-binding proteins comprise a subgroup of the Rho GTPase family that show a specific expression pattern similar to the Notch signal component ESR5, suggesting an association between Rnd1/3 and the segmentation clock. Rnd1/3 expression patterns are disrupted by overexpression of dominant-negative or active forms of Notch signaling genes, and responds to the FGF inhibitor SU5402 by a posterior shift analogous to other segmentation-related genes, suggesting that Rnd1/3 expressions are regulated by the segmentation clock machinery. We also show that antisense morpholino oligonucleotides to Rnd1/3 inhibit somite segmentation and differentiation in Xenopus embryos. These results suggest that Rnd1/3 are required for Xenopus somitogenesis. Developmental Dynamics, 2009. (c) 2009 Wiley-Liss, Inc.}, author = {Goda, Tadahiro and Takagi, Chiyo and Ueno, Naoto}, citeulike-article-id = {5972857}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/dvdy.22099}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19795516}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19795516}, day = {30}, doi = {10.1002/dvdy.22099}, journal = {Developmental dynamics : an official publication of the American Association of Anatomists}, keywords = {segmentation, xenopus}, month = {September}, posted-at = {2009-10-20 02:45:51}, priority = {2}, title = {Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation.}, url = {http://dx.doi.org/10.1002/dvdy.22099}, year = {2009} }

TY - JOUR ID - citeulike:5972857 L3 - citeulike-article-id:5972857 N2 - The process of segmentation in vertebrates is described by a clock and wavefront model consisting of a Notch signal and an fibroblast growth factor-8 (FGF8) gradient, respectively. To further investigate the segmentation process, we screened gene expression profiles for downstream targets of the segmentation clock. The Rnd1 and Rnd3 GTP-binding proteins comprise a subgroup of the Rho GTPase family that show a specific expression pattern similar to the Notch signal component ESR5, suggesting an association between Rnd1/3 and the segmentation clock. Rnd1/3 expression patterns are disrupted by overexpression of dominant-negative or active forms of Notch signaling genes, and responds to the FGF inhibitor SU5402 by a posterior shift analogous to other segmentation-related genes, suggesting that Rnd1/3 expressions are regulated by the segmentation clock machinery. We also show that antisense morpholino oligonucleotides to Rnd1/3 inhibit somite segmentation and differentiation in Xenopus embryos. These results suggest that Rnd1/3 are required for Xenopus somitogenesis. Developmental Dynamics, 2009. (c) 2009 Wiley-Liss, Inc. JF - Developmental dynamics : an official publication of the American Association of Anatomists TI - Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation. KW - segmentation KW - xenopus AU - Goda, Tadahiro AU - Takagi, Chiyo AU - Ueno, Naoto PY - 2009/09/30/ UR - http://dx.doi.org/10.1002/dvdy.22099 ER -