The structure and function of G-protein-coupled receptors Export

@article{citeulike:4567709, abstract = {G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.}, author = {Rosenbaum, Daniel M. and Rasmussen, Soren G. F. and Kobilka, Brian K.}, citeulike-article-id = {4567709}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08144}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08144}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19458711}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19458711}, day = {20}, doi = {10.1038/nature08144}, issn = {0028-0836}, journal = {Nature}, keywords = {gpcr}, month = {May}, number = {7245}, pages = {356--363}, posted-at = {2009-07-02 20:27:18}, priority = {2}, publisher = {Nature Publishing Group}, title = {The structure and function of G-protein-coupled receptors}, url = {http://dx.doi.org/10.1038/nature08144}, volume = {459}, year = {2009} }

TY - JOUR ID - citeulike:4567709 L3 - citeulike-article-id:4567709 N2 - G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity. IS - 7245 JF - Nature SN - 0028-0836 EP - 363 TI - The structure and function of G-protein-coupled receptors PB - Nature Publishing Group VL - 459 SP - 356 KW - gpcr AU - Rosenbaum, Daniel AU - Rasmussen, Soren AU - Kobilka, Brian PY - 2009/05/20/ UR - http://dx.doi.org/10.1038/nature08144 ER -