Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Export

@article{citeulike:2802900, abstract = {When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.}, author = {Zon, Leonard I.}, citeulike-article-id = {2802900}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07038}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18480811}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18480811}, citeulike-linkout-3 = {http://zon.tchlab.org/nature07038.pdf}, citeulike-linkout-4 = {http://scholar.google.com/scholar?cluster=9613616191360375895}, day = {15}, doi = {10.1038/nature07038}, issn = {1476-4687}, journal = {Nature}, keywords = {hematopoi, niche, revu, signaling}, month = {May}, number = {7193}, pages = {306--313}, posted-at = {2009-11-09 17:41:45}, priority = {2}, publisher = {Nature Publishing Group}, title = {Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal.}, url = {http://dx.doi.org/10.1038/nature07038}, volume = {453}, year = {2008} }

TY - JOUR ID - citeulike:2802900 L3 - citeulike-article-id:2802900 N2 - When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues. IS - 7193 JF - Nature SN - 1476-4687 EP - 313 TI - Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. PB - Nature Publishing Group VL - 453 SP - 306 KW - hematopoi KW - niche KW - revu KW - signaling AU - Zon, Leonard PY - 2008/05/15/ UR - http://dx.doi.org/10.1038/nature07038 ER -