Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. Export

@article{citeulike:4036333, abstract = {The excessive growth of a tumor requires high rates of glucose uptake and glycolysis and continuous recruitment of new blood vessels. Here, we provide several lines of evidence showing that pyruvic acid, the end product of glycolysis, exhibits strong angiogenic activity. Pyruvic acid promoted angiogenesis in chorioallantoic membrane assay and in vivo mouse Matrigel plug assay. Pyruvic acid also positively affects angiogenic cascade, DNA synthesis, migration, and tube formation in bovine aortic endothelial cells. Furthermore, mRNA expression of fibroblast growth factor receptor-2 and vascular endothelial growth factor was enhanced by pyruvic acid. These results strongly suggest that pyruvic acid plays an important role in angiogenesis for tumor growth and metastasis.}, author = {Lee, M. S. and Moon, E. J. and Lee, S. W. and Kim, M. S. and Kim, K. W. and Kim, Y. J.}, citeulike-article-id = {4036333}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11309282}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11309282}, citeulike-linkout-2 = {http://cancerres.aacrjournals.org/cgi/content/full/61/8/3290}, day = {15}, issn = {0008-5472}, journal = {Cancer research}, keywords = {angio\_model, angiogenesis, glycolysis, warburg}, month = {April}, number = {8}, pages = {3290--3293}, posted-at = {2009-02-11 18:01:54}, priority = {2}, title = {Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11309282}, volume = {61}, year = {2001} }

TY - JOUR ID - citeulike:4036333 L3 - citeulike-article-id:4036333 N2 - The excessive growth of a tumor requires high rates of glucose uptake and glycolysis and continuous recruitment of new blood vessels. Here, we provide several lines of evidence showing that pyruvic acid, the end product of glycolysis, exhibits strong angiogenic activity. Pyruvic acid promoted angiogenesis in chorioallantoic membrane assay and in vivo mouse Matrigel plug assay. Pyruvic acid also positively affects angiogenic cascade, DNA synthesis, migration, and tube formation in bovine aortic endothelial cells. Furthermore, mRNA expression of fibroblast growth factor receptor-2 and vascular endothelial growth factor was enhanced by pyruvic acid. These results strongly suggest that pyruvic acid plays an important role in angiogenesis for tumor growth and metastasis. IS - 8 JF - Cancer research SN - 0008-5472 EP - 3293 TI - Angiogenic activity of pyruvic acid in in vivo and in vitro angiogenesis models. VL - 61 SP - 3290 KW - angio_model KW - angiogenesis KW - glycolysis KW - warburg AU - Lee, MS AU - Moon, EJ AU - Lee, SW AU - Kim, MS AU - Kim, KW AU - Kim, YJ PY - 2001/04/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11309282 ER -