Genentech's new parADigm Export

@article{citeulike:4112741, abstract = {A study by a team at Genentech Inc. proposes a new mechanism for Alzheimer's disease pathogenesis by outlining a process that could be an early step in the neurodegenerative disorder.1 The work also identifies a trio of new AD targets, which the company is pursuing with preclinical programs. The study suggests that the previously ignored amino-terminal portion of amyloid precursor protein (APP), called N-APP, might be the main culprit behind AD. APP is a transmembrane protein that gives rise to N-APP and the much more commonly known beta-amyloid (Abeta), a fragment that forms the amyloid fibers and plaques that are hallmarks of AD, although the precise role of those fibers and plaques in disease pathology is unclear.2}, author = {Osherovich, Lev}, citeulike-article-id = {4112741}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/scibx.2009.300}, citeulike-linkout-1 = {http://http://www.nature.com/scibx/journal/v2/n8/full/scibx.2009.300.html}, day = {26}, doi = {10.1038/scibx.2009.300}, issn = {1945-3477}, journal = {Science-Business eXchange}, keywords = {regen\_neuro, scibx}, month = {February}, number = {8}, pages = {1--5}, posted-at = {2009-02-27 17:36:34}, priority = {2}, title = {Genentech's new parADigm}, url = {http://dx.doi.org/10.1038/scibx.2009.300}, volume = {2}, year = {2009} }

TY - JOUR ID - citeulike:4112741 L3 - citeulike-article-id:4112741 N2 - A study by a team at Genentech Inc. proposes a new mechanism for Alzheimer's disease pathogenesis by outlining a process that could be an early step in the neurodegenerative disorder.1 The work also identifies a trio of new AD targets, which the company is pursuing with preclinical programs. The study suggests that the previously ignored amino-terminal portion of amyloid precursor protein (APP), called N-APP, might be the main culprit behind AD. APP is a transmembrane protein that gives rise to N-APP and the much more commonly known beta-amyloid (Abeta), a fragment that forms the amyloid fibers and plaques that are hallmarks of AD, although the precise role of those fibers and plaques in disease pathology is unclear.2 IS - 8 JF - Science-Business eXchange SN - 1945-3477 EP - 5 TI - Genentech's new parADigm VL - 2 SP - 1 KW - regen_neuro KW - scibx AU - Osherovich, Lev PY - 2009/02/26/ UR - http://dx.doi.org/10.1038/scibx.2009.300 ER -