7-Hydroxy androstene steroids and a novel synthetic analogue with reduced side effects as a potential agent to treat autoimmune diseases. Export

@article{citeulike:4195585, abstract = {The metabolome of dehydroepiandrosterone (DHEA), the most abundant adrenal steroid in the human body, includes androgens, estrogens and a series of immune regulating hormones that lack androgenic or estrogenic activity. Of these, 7-hydroxy derivatives, once considered physiologically inactive end products of metabolism, possess a combination of potent anti-inflammatory and immune modulating activity without androgenic or estrogenic capacity. Oxygenated metabolites derived from androstenediol (AED), the predominant precursor in rodents, may be responsible for many activities initially attributed to exogenous DHEA administered to rodents. We here review the discovery of these compounds in models of inflammation and autoimmune diseases, discuss the potential mode of action and trace the development of a specific synthetic derivative, which is less labile to metabolism and which may at last deliver to humans the benefits of DHEA observed in rodents.}, author = {Auci, D. L. and Reading, C. L. and Frincke, J. M.}, citeulike-article-id = {4195585}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.autrev.2008.11.011}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19071234}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19071234}, citeulike-linkout-3 = {http://scholar.google.com/scholar?cluster=12852924495101498089}, doi = {10.1016/j.autrev.2008.11.011}, issn = {1873-0183}, journal = {Autoimmunity reviews}, keywords = {aed, aet, autoimmunity, dhea\_analog, dhea\_metab, heph\_compds, hephpubs, steroid\_inflam}, month = {March}, number = {5}, pages = {369--372}, posted-at = {2009-03-19 17:24:23}, priority = {2}, title = {7-Hydroxy androstene steroids and a novel synthetic analogue with reduced side effects as a potential agent to treat autoimmune diseases.}, url = {http://dx.doi.org/10.1016/j.autrev.2008.11.011}, volume = {8}, year = {2009} }

TY - JOUR ID - citeulike:4195585 L3 - citeulike-article-id:4195585 N2 - The metabolome of dehydroepiandrosterone (DHEA), the most abundant adrenal steroid in the human body, includes androgens, estrogens and a series of immune regulating hormones that lack androgenic or estrogenic activity. Of these, 7-hydroxy derivatives, once considered physiologically inactive end products of metabolism, possess a combination of potent anti-inflammatory and immune modulating activity without androgenic or estrogenic capacity. Oxygenated metabolites derived from androstenediol (AED), the predominant precursor in rodents, may be responsible for many activities initially attributed to exogenous DHEA administered to rodents. We here review the discovery of these compounds in models of inflammation and autoimmune diseases, discuss the potential mode of action and trace the development of a specific synthetic derivative, which is less labile to metabolism and which may at last deliver to humans the benefits of DHEA observed in rodents. IS - 5 JF - Autoimmunity reviews SN - 1873-0183 EP - 372 TI - 7-Hydroxy androstene steroids and a novel synthetic analogue with reduced side effects as a potential agent to treat autoimmune diseases. VL - 8 SP - 369 KW - aed KW - aet KW - autoimmunity KW - dhea_analog KW - dhea_metab KW - heph_compds KW - hephpubs KW - steroid_inflam AU - Auci, DL AU - Reading, CL AU - Frincke, JM PY - 2009/03// UR - http://dx.doi.org/10.1016/j.autrev.2008.11.011 ER -