Sex steroids and stem cell function. Export

@article{citeulike:5257602, abstract = {Gender dimorphisms exist in the pathogenesis of a variety of cardiovascular, cardiopulmonary, neurodegenerative, and endocrine disorders. Estrogens exert immense influence on myocardial remodeling following ischemic insult, partially through paracrine growth hormone production by bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells. Estrogens also facilitate the mobilization of endothelial progenitor cells to the ischemic myocardium and enhance neovascularization at the ischemic border zone. Moreover, estrogens limit pathological myocardial remodeling through the inhibitory effects on the proliferation of the cardiac fibroblasts. Androgens also may stimulate endothelial progenitor cell migration from the bone marrow, yet the larger role of androgens in disease pathogenesis is not well characterized. The beneficial effects of sex steroids include alteration of lipid metabolism in preadipocytes, modulation of bone metabolism and skeletal maturation, and prevention of osteoporosis through their effects on osteogenic precursors. In an example of sex steroid-specific effects, neural stem cells exhibit enhanced proliferation in response to estrogens, whereas androgens mediate inhibitory effects on their proliferation. Although stem cells can offer significant therapeutic benefits in various cardiovascular, neurodegenerative, endocrine disorders, and disorders of bone metabolism, a greater understanding of sex hormones on diverse stem cell populations is required to improve their ultimate clinical efficacy. In this review, we focus on the effects of estrogen and testosterone on various stem and progenitor cell types, and their relevant intracellular mechanisms.}, author = {Ray, R. and Novotny, N. M. and Crisostomo, P. R. and Lahm, T. and Abarbanell, A. and Meldrum, D. R.}, citeulike-article-id = {5257602}, citeulike-linkout-0 = {http://dx.doi.org/10.2119/2008-00004.Ray}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18475312}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18475312}, citeulike-linkout-3 = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18475312}, citeulike-linkout-4 = {http://scholar.google.com/scholar?cites=13251652984691337317}, doi = {10.2119/2008-00004.Ray}, issn = {1076-1551}, journal = {Molecular medicine (Cambridge, Mass.)}, keywords = {1one, hematopoi\_steroid, revu}, number = {7-8}, pages = {493--501}, posted-at = {2009-07-25 05:25:43}, priority = {2}, title = {Sex steroids and stem cell function.}, url = {http://dx.doi.org/10.2119/2008-00004.Ray}, volume = {14}, year = {2008} }

TY - JOUR ID - citeulike:5257602 L3 - citeulike-article-id:5257602 N2 - Gender dimorphisms exist in the pathogenesis of a variety of cardiovascular, cardiopulmonary, neurodegenerative, and endocrine disorders. Estrogens exert immense influence on myocardial remodeling following ischemic insult, partially through paracrine growth hormone production by bone marrow mesenchymal stem cells (MSCs) and endothelial progenitor cells. Estrogens also facilitate the mobilization of endothelial progenitor cells to the ischemic myocardium and enhance neovascularization at the ischemic border zone. Moreover, estrogens limit pathological myocardial remodeling through the inhibitory effects on the proliferation of the cardiac fibroblasts. Androgens also may stimulate endothelial progenitor cell migration from the bone marrow, yet the larger role of androgens in disease pathogenesis is not well characterized. The beneficial effects of sex steroids include alteration of lipid metabolism in preadipocytes, modulation of bone metabolism and skeletal maturation, and prevention of osteoporosis through their effects on osteogenic precursors. In an example of sex steroid-specific effects, neural stem cells exhibit enhanced proliferation in response to estrogens, whereas androgens mediate inhibitory effects on their proliferation. Although stem cells can offer significant therapeutic benefits in various cardiovascular, neurodegenerative, endocrine disorders, and disorders of bone metabolism, a greater understanding of sex hormones on diverse stem cell populations is required to improve their ultimate clinical efficacy. In this review, we focus on the effects of estrogen and testosterone on various stem and progenitor cell types, and their relevant intracellular mechanisms. IS - 7-8 JF - Molecular medicine (Cambridge, Mass.) SN - 1076-1551 EP - 501 TI - Sex steroids and stem cell function. VL - 14 SP - 493 KW - 1one KW - hematopoi_steroid KW - revu AU - Ray, R AU - Novotny, NM AU - Crisostomo, PR AU - Lahm, T AU - Abarbanell, A AU - Meldrum, DR PY - 2008///g UR - http://dx.doi.org/10.2119/2008-00004.Ray ER -