The Pathophysiologic Roles of Interleukin-6 in Human Disease Export

@article{citeulike:5907354, abstract = {Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and metabolic actions. Specifically, it is a potent stimulator of the hypothalamic-pituitary-adrenal axis and is under the tonic negative control of glucocorticoids. It acutely stimulates the secretion of growth hormone, inhibits thyroid-stimulating hormone secretion, and decreases serum lipid concentrations. Furthermore, it is secreted during stress and is positively controlled by catecholamines. Administration of interleukin-6 results in fever, anorexia, and fatigue. Elevated levels of circulating interleukin-6 have been seen in the steroid withdrawal syndrome and in the severe inflammatory, infectious, and traumatic states potentially associated with the inappropriate secretion of vasopressin. Levels of circulating interleukin-6 are also elevated in several inflammatory diseases, such as rheumatoid arthritis. Interleukin-6 is negatively controlled by estrogens and androgens, and it plays a central role in the pathogenesis of the osteoporosis seen in conditions characterized by increased bone resorption, such as sex-steroid deficiency and hyperparathyroidism. Overproduction of interleukin-6 may contribute to illness during aging and chronic stress. Finally, administration of recombinant human interleukin-6 may serve as a stimulation test for the integrity of the hypothalamic-pituitary-adrenal axis.}, author = {Papanicolaou, Dimitris A. and Wilder, Ronald L. and Manolagas, Stavros C. and Chrousos, George P.}, citeulike-article-id = {5907354}, citeulike-linkout-0 = {http://www.annals.org/content/128/2/127.abstract}, citeulike-linkout-1 = {http://www.annals.org/content/128/2/127.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9441573}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9441573}, day = {15}, journal = {Ann Intern Med}, keywords = {aging\_cytokineprofile, il6, il6-n-bone, ra}, month = {January}, number = {2}, pages = {127--137}, posted-at = {2009-10-07 20:53:58}, priority = {2}, title = {The Pathophysiologic Roles of Interleukin-6 in Human Disease}, url = {http://www.annals.org/content/128/2/127.abstract}, volume = {128}, year = {1998} }

TY - JOUR ID - citeulike:5907354 L3 - citeulike-article-id:5907354 N2 - Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and metabolic actions. Specifically, it is a potent stimulator of the hypothalamic-pituitary-adrenal axis and is under the tonic negative control of glucocorticoids. It acutely stimulates the secretion of growth hormone, inhibits thyroid-stimulating hormone secretion, and decreases serum lipid concentrations. Furthermore, it is secreted during stress and is positively controlled by catecholamines. Administration of interleukin-6 results in fever, anorexia, and fatigue. Elevated levels of circulating interleukin-6 have been seen in the steroid withdrawal syndrome and in the severe inflammatory, infectious, and traumatic states potentially associated with the inappropriate secretion of vasopressin. Levels of circulating interleukin-6 are also elevated in several inflammatory diseases, such as rheumatoid arthritis. Interleukin-6 is negatively controlled by estrogens and androgens, and it plays a central role in the pathogenesis of the osteoporosis seen in conditions characterized by increased bone resorption, such as sex-steroid deficiency and hyperparathyroidism. Overproduction of interleukin-6 may contribute to illness during aging and chronic stress. Finally, administration of recombinant human interleukin-6 may serve as a stimulation test for the integrity of the hypothalamic-pituitary-adrenal axis. IS - 2 JF - Ann Intern Med EP - 137 TI - The Pathophysiologic Roles of Interleukin-6 in Human Disease VL - 128 SP - 127 KW - aging_cytokineprofile KW - il6 KW - il6-n-bone KW - ra AU - Papanicolaou, Dimitris AU - Wilder, Ronald AU - Manolagas, Stavros AU - Chrousos, George PY - 1998/01/15/ UR - http://www.annals.org/content/128/2/127.abstract ER -