Osteogenetic potency and new-bone formation by induction in transplants to the anterior chamber of the eye. Export

@article{citeulike:6060723, abstract = {[ABSTRACT/INTRODUCTION] New-bone has been produced in tissue cultures (15, 42, 51), grown from transplants(9, 16, 21, 28), and described in pathological conditions of almost every organ in the body(2, 29). The nature of the osteogenetic principle which initiates and sustains the process of new-bone formation is a fundamental problem of osteogenesis. Beginning with the work of Barth in 1893, numerous histological observations have been reported in the literature to suggest, in some form, the hypothesis that new-bone formation is activated by those osteogenetic principles by which undifferentiated connective-tissue cells are transformed into bone cells. The experiments presented in this paper demonstrate the osteogenetic activity of 250 samples of various kinds of musculoskeletal tissues transferred to the anterior chamber of the eye. The eye facilitated continuous observation and recovery of the transplant, and excluded any direct contact with the skeleton of the host. Under such conditions "osteogenetic potency"--the capacity of the tissue to produce new bone--was exhibited by certain cells in the periosteum, cancellous bone, and bone-marrow reticulum which survived autogenous transplantation. This potency becomes manifest. as "osteogenetic activity", expressed as actual formation of bone by survival and proliferation of transplanted cells. When, on the other hand, the ingrowing cells of the host--in this case in the eye--are "induced" to form bone by contact with the substance of a transplanted tissue as described below, the process is that of "induction". The process of induction elicits a potency in the ingrowing connective-tissue cells which otherwise might have remained latent.. The nature of the induction process and the mechanisms, both physical and chemical, which may be involved have been developed in the field of experimental embryology and have been reviewed in detail by Weiss (62, 63, 64)}, author = {Urist, Marshall R. and McLean, Franklin C.}, citeulike-article-id = {6060723}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14917713}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14917713}, citeulike-linkout-2 = {http://www.ejbjs.org/cgi/content/abstract/34/2/443}, citeulike-linkout-3 = {http://scholar.google.com/scholar?cluster=8971294895527800876}, issn = {0021-9355}, journal = {The Journal of bone and joint surgery. American volume}, keywords = {eye-anteriorchamber-transplantation-model, historical, msc\_osteo, osteo\_model}, month = {April}, number = {2}, pages = {443--476}, posted-at = {2009-11-03 16:59:00}, priority = {2}, title = {Osteogenetic potency and new-bone formation by induction in transplants to the anterior chamber of the eye.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14917713}, volume = {34-A}, year = {1952} }

TY - JOUR ID - citeulike:6060723 L3 - citeulike-article-id:6060723 N2 - [ABSTRACT/INTRODUCTION] New-bone has been produced in tissue cultures (15, 42, 51), grown from transplants(9, 16, 21, 28), and described in pathological conditions of almost every organ in the body(2, 29). The nature of the osteogenetic principle which initiates and sustains the process of new-bone formation is a fundamental problem of osteogenesis. Beginning with the work of Barth in 1893, numerous histological observations have been reported in the literature to suggest, in some form, the hypothesis that new-bone formation is activated by those osteogenetic principles by which undifferentiated connective-tissue cells are transformed into bone cells. The experiments presented in this paper demonstrate the osteogenetic activity of 250 samples of various kinds of musculoskeletal tissues transferred to the anterior chamber of the eye. The eye facilitated continuous observation and recovery of the transplant, and excluded any direct contact with the skeleton of the host. Under such conditions "osteogenetic potency"--the capacity of the tissue to produce new bone--was exhibited by certain cells in the periosteum, cancellous bone, and bone-marrow reticulum which survived autogenous transplantation. This potency becomes manifest. as "osteogenetic activity", expressed as actual formation of bone by survival and proliferation of transplanted cells. When, on the other hand, the ingrowing cells of the host--in this case in the eye--are "induced" to form bone by contact with the substance of a transplanted tissue as described below, the process is that of "induction". The process of induction elicits a potency in the ingrowing connective-tissue cells which otherwise might have remained latent.. The nature of the induction process and the mechanisms, both physical and chemical, which may be involved have been developed in the field of experimental embryology and have been reviewed in detail by Weiss (62, 63, 64) IS - 2 JF - The Journal of bone and joint surgery. American volume SN - 0021-9355 EP - 476 TI - Osteogenetic potency and new-bone formation by induction in transplants to the anterior chamber of the eye. VL - 34-A SP - 443 KW - eye-anteriorchamber-transplantation-model KW - historical KW - msc_osteo KW - osteo_model AU - Urist, Marshall AU - McLean, Franklin PY - 1952/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/14917713 ER -