The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus Export

@article{citeulike:6071779, abstract = {Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (n = 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (n = 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes.}, author = {Chen, Hua and Liu, Ya-qian and Li, Chun-hai and Guo, Xiong-ming and Huang, Li-jie}, citeulike-article-id = {6071779}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/laban1109-355}, citeulike-linkout-1 = {http://www.labanimal.com/laban/journal/v38/n11/abs/laban1109-355.html}, doi = {10.1038/laban1109-355}, issn = {0093-7355}, journal = {Lab Animal}, keywords = {pig-model, t2dm\_model}, month = {November}, number = {11}, pages = {355--363}, posted-at = {2009-11-04 23:45:54}, priority = {2}, title = {The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus}, url = {http://dx.doi.org/10.1038/laban1109-355}, volume = {38}, year = {2009} }

TY - JOUR ID - citeulike:6071779 L3 - citeulike-article-id:6071779 N2 - Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (n = 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (n = 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes. IS - 11 JF - Lab Animal SN - 0093-7355 EP - 363 TI - The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus VL - 38 SP - 355 KW - pig-model KW - t2dm_model AU - Chen, Hua AU - Liu, Ya-qian AU - Li, Chun-hai AU - Guo, Xiong-ming AU - Huang, Li-jie PY - 2009/11// UR - http://dx.doi.org/10.1038/laban1109-355 ER -